Interleukin 2 Receptor Alpha (IL2Ra)
[Edit]CD25; IL2R-a; IL2-RA; IDDM10; IL2R; TCGFR; p55; TAC antigen
CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2.CD25 expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.
Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB837Mu01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPB837Mu02 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APB837Mu02 | Active Interleukin 2 Receptor Alpha (IL2Ra) | Cell culture; Activity Assays. | |
Antibodies | PAB837Mu02 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
PAB837Mu01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. | |
Assay Kits | SEB837Mu | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB837Ra01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPB837Ra02 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAB837Ra01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
PAB837Ra02 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. | |
LAB837Ra71 | Biotin-Linked Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC. | |
LAB837Ra81 | FITC-Linked Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
PAB837Ra03 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. | |
Assay Kits | SEB837Ra | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB837Po01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB837Po01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB837Bo01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB837Bo01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
MAB837Bo21 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. | |
Assay Kits | SEB837Bo | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Molecular cloning of cDNA encoding human interleukin-2 receptor."Nature 311:631-635(1984) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning and expression of cDNAs for the human interleukin-2 receptor."Nature 311:626-631(1984) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning and structure of the human interleukin 2 receptor gene."Nucleic Acids Res. 13:7579-7589(1985) [PubMed] [Europe PMC] [Abstract]
- "Structure of the human interleukin-2 receptor gene."Science 230:633-639(1985) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I."Cell 49:47-56(1987) [PubMed] [Europe PMC] [Abstract]
- "Structural analysis of recombinant soluble human interleukin-2 receptor. Primary structure, assignment of disulfide bonds and core IL-2 binding structure."Biochem. Biophys. Res. Commun. 154:372-379(1988) [PubMed] [Europe PMC] [Abstract]
- "The interleukin-2 and interleukin-4 receptors studied by molecular modelling."Structure 2:839-851(1994) [PubMed] [Europe PMC] [Abstract]
- "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."Science 310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]
- "Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes."Nat. Genet. 39:1074-1082(2007) [PubMed] [Europe PMC] [Abstract]