Transglutaminase 2 (TGM2)
[Edit]tTG; TG2; C Polypeptide,Protein-Glutamine-Gamma-Glutamyltransferase; Transglutaminase 2, Tissue; Transglutaminase C; Transglutaminase H
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Tissue transglutaminase is an enzyme (EC 2.3.2.13) of the transglutaminase family. Like other transglutaminases, it crosslinks proteins between an ε-amino group of a lysine residue and a γ-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation).
It is particularly notable for being the autoantigen in coeliac disease, but is also known to play a role in apoptosis, cellular differentiation and matrix stabilisation. tTG is expressed ubiquitously. It requires calcium as a cofactor for transamidation activity. Transcription is increased by retinoic acid. Amongst its many supposed functions, it appears to play a role in wound healing, apoptosis and extracellular matrix development
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB830Hu01 | Recombinant Transglutaminase 2 (TGM2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB830Hu01 | Active Transglutaminase 2 (TGM2) | Cell culture; Activity Assays. | |
| Antibodies | PAB830Hu01 | Polyclonal Antibody to Transglutaminase 2 (TGM2) | WB,IHC,ICC/IF |
| MAB830Hu22 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. | |
| LAB830Hu71 | Biotin-Linked Polyclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC. | |
| Assay Kits | SEB830Hu | ELISA Kit for Transglutaminase 2 (TGM2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB830Hu | CLIA Kit for Transglutaminase 2 (TGM2) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEB830Hu | High Sensitive ELISA Kit for Transglutaminase 2 (TGM2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB830Mu01 | Recombinant Transglutaminase 2 (TGM2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAB830Mu21 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. |
| MAB830Mu22 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. | |
| MAB830Mu23 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. | |
| MAB830Mu24 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. | |
| MAB830Mu25 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. | |
| MAB830Mu27 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Transglutaminase 2 (TGM2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Transglutaminase 2 (TGM2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB830Ra01 | Recombinant Transglutaminase 2 (TGM2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB830Ra01 | Polyclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. |
| MAB830Ra21 | Monoclonal Antibody to Transglutaminase 2 (TGM2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB830Ra | ELISA Kit for Transglutaminase 2 (TGM2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases."J. Biol. Chem. 266:478-483(1991) [PubMed] [Europe PMC] [Abstract]
- "A retinoic acid-inducible mRNA from human erythroleukemia cells encodes a novel tissue transglutaminase homologue."J. Biol. Chem. 267:22616-22623(1992) [PubMed] [Europe PMC] [Abstract]
- "A third human tissue transglutaminase homologue as a result of alternative gene transcripts."Biochim. Biophys. Acta 1306:63-74(1996) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]