Transglutaminase 2 (TGM2)

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tTG; TG2; C Polypeptide,Protein-Glutamine-Gamma-Glutamyltransferase; Transglutaminase 2, Tissue; Transglutaminase C; Transglutaminase H

Transglutaminase 2 (TGM2)
  • Tissue transglutaminase  is an enzyme (EC 2.3.2.13) of the transglutaminase family. Like other transglutaminases, it crosslinks proteins between an ε-amino group of a lysine residue and a γ-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation).

  • It is particularly notable for being the autoantigen in coeliac disease, but is also known to play a role in apoptosis, cellular differentiation and matrix stabilisation. tTG is expressed ubiquitously. It requires calcium as a cofactor for transamidation activity. Transcription is increased by retinoic acid. Amongst its many supposed functions, it appears to play a role in wound healing, apoptosis and extracellular matrix development

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB830Hu01 Recombinant Transglutaminase 2 (TGM2) Positive Control; Immunogen; SDS-PAGE; WB.
APB830Hu01 Active Transglutaminase 2 (TGM2) Cell culture; Activity Assays.
Antibodies PAB830Hu01 Polyclonal Antibody to Transglutaminase 2 (TGM2) WB,IHC,ICC/IF
MAB830Hu22 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
LAB830Hu71 Biotin-Linked Polyclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC.
Assay Kits SEB830Hu ELISA Kit for Transglutaminase 2 (TGM2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB830Hu CLIA Kit for Transglutaminase 2 (TGM2) Chemiluminescent immunoassay for Antigen Detection.
HEB830Hu High Sensitive ELISA Kit for Transglutaminase 2 (TGM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB830Mu01 Recombinant Transglutaminase 2 (TGM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB830Mu21 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
MAB830Mu22 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
MAB830Mu23 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
MAB830Mu24 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
MAB830Mu25 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
MAB830Mu27 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transglutaminase 2 (TGM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transglutaminase 2 (TGM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB830Ra01 Recombinant Transglutaminase 2 (TGM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB830Ra01 Polyclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
MAB830Ra21 Monoclonal Antibody to Transglutaminase 2 (TGM2) WB; IHC; ICC; IP.
Assay Kits SEB830Ra ELISA Kit for Transglutaminase 2 (TGM2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases."J. Biol. Chem. 266:478-483(1991) [PubMed] [Europe PMC] [Abstract]
  2. "A retinoic acid-inducible mRNA from human erythroleukemia cells encodes a novel tissue transglutaminase homologue."J. Biol. Chem. 267:22616-22623(1992) [PubMed] [Europe PMC] [Abstract]
  3. "A third human tissue transglutaminase homologue as a result of alternative gene transcripts."Biochim. Biophys. Acta 1306:63-74(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]