A Disintegrin And Metalloprotease 9 (ADAM9)
[Edit]MCMP; MDC9; Mltng; Meltrin Gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase; Cellular disintegrin-related protein
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Disintegrin and metalloproteinase domain-containing protein 9 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB829Hu01 | Recombinant A Disintegrin And Metalloprotease 9 (ADAM9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB829Hu01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | WB; IHC; ICC; IP. |
| MAB829Hu22 | Monoclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | WB; IHC; ICC; IP. | |
| LAB829Hu81 | FITC-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | WB; IHC; ICC; IF. | |
| LAB829Hu71 | Biotin-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | WB; IHC; ICC. | |
| Assay Kits | SEB829Hu | ELISA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant A Disintegrin And Metalloprotease 9 (ADAM9) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB829Ra01 | Recombinant A Disintegrin And Metalloprotease 9 (ADAM9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB829Ra01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | WB; IHC; ICC; IP. |
| MAB829Ra21 | Monoclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB829Ra | ELISA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB829Ra | CLIA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) | Chemiluminescent immunoassay for Antigen Detection. |
- "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains."J. Cell Biol. 132:717-726(1996) [PubMed] [Europe PMC] [Abstract]
- "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells."Biochem. J. 318:459-462(1996) [PubMed] [Europe PMC] [Abstract]
- "A secreted form of human ADAM9 has an alpha-secretase activity for APP."Biochem. Biophys. Res. Commun. 293:800-805(2002) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."Biochem. Biophys. Res. Commun. 230:335-339(1997) [PubMed] [Europe PMC] [Abstract]
- "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice." Am. J. Hum. Genet. 84:683-691(2009) [PubMed] [Europe PMC] [Abstract]
- "Exploring the substrate affinities of MMP-3, ADAM-9 and ADAM-10 using molecular modelling and dynamics simulations."Submitted (JUN-2002) to the PDB data bank