≡

Nuclear Factor Kappa B (NFkB)

[Edit]

NF-KB1; EBP-1; KBF1; NF-Kappa-B; NFKB-P105; NFKB-P50; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; Nuclear factor NF-kappa-B p105 subunit

Nuclear Factor Kappa B (NFkB)
CCC B824
HGNC 7794
MGI 97312
PubMed 15856292
RGD 70498
UniProt P19838
Wiki NFKB1
Nuclear factor NF-kappa-B p105 subunit isa 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex.
NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB824Hu01 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB824Hu02 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB824Hu03 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB824Hu01 Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
MAB824Hu22 Monoclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
LAB824Hu71 Biotin-Linked Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC.
LAB824Hu81 FITC-Linked Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IF.
PAB824Hu02 Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
Assay Kits SEB824Hu ELISA Kit for Nuclear Factor Kappa B (NFkB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB824Mu01 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB824Mu01 Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
LAB824Mu71 Biotin-Linked Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC.
LAB824Mu81 FITC-Linked Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IF.
Assay Kits SEB824Mu ELISA Kit for Nuclear Factor Kappa B (NFkB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB824Ra01 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB824Ra01 Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
MAB824Ra21 Monoclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
Assay Kits SEB824Ra ELISA Kit for Nuclear Factor Kappa B (NFkB) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB824Ra CLIA Kit for Nuclear Factor Kappa B (NFkB) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Kappa B (NFkB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Kappa B (NFkB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) Polyclonal Antibody Customized Service Offer
Assay Kits SEB824Rb ELISA Kit for Nuclear Factor Kappa B (NFkB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB824Bo01 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB824Bo01 Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nuclear Factor Kappa B (NFkB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Kappa B (NFkB) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB824Ga01 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB824Ga01 Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
MAB824Ga21 Monoclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
Assay Kits SEB824Ga ELISA Kit for Nuclear Factor Kappa B (NFkB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB824Fi01 Recombinant Nuclear Factor Kappa B (NFkB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB824Fi01 Polyclonal Antibody to Nuclear Factor Kappa B (NFkB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nuclear Factor Kappa B (NFkB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Kappa B (NFkB) ELISA Kit Customized Service Offer
  1. "The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product."Cell 62:1007-1018(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs."Nature 348:76-80(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha."Proc. Natl. Acad. Sci. U.S.A. 88:966-970(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction."Genomics 30:493-505(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene."EMBO J. 11:205-213(1992) [PubMed] [Europe PMC] [Abstract]
  9. "The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B."Cell 78:773-785(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor."Oncogene 9:1487-1492(1994) [PubMed] [Europe PMC] [Abstract]
  11. "A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit."Mol. Cell. Biol. 16:2248-2254(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Inhibition of NF-kappaB DNA binding by nitric oxide."Nucleic Acids Res. 24:2236-2242(1996) [PubMed] [Europe PMC] [Abstract]
  13. "A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription."Mol. Cell. Biol. 17:6184-6190(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome."Cell 92:819-828(1998) [PubMed] [Europe PMC] [Abstract]
  15. "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes."EMBO J. 18:4766-4778(1999) [PubMed] [Europe PMC] [Abstract]
  16. "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105."Nature 397:363-368(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production."EMBO J. 19:4712-4722(2000) [PubMed] [Europe PMC] [Abstract]
  18. "RAC-3 is a NF-kappa B coactivator."FEBS Lett. 485:195-199(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Inhibition of NF-kappaB by S-nitrosylation."Biochemistry 40:1688-1693(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B."Blood 98:743-753(2001) [PubMed] [Europe PMC] [Abstract]
  21. "15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit."J. Biol. Chem. 276:35530-35536(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis."J. Biol. Chem. 276:22215-22222(2001) [PubMed] [Europe PMC] [Abstract]
  23. "The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."Oncogene 20:4917-4925(2001) [PubMed] [Europe PMC] [Abstract]
  24. "Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105."Biochem. Biophys. Res. Commun. 309:980-985(2003) [PubMed] [Europe PMC] [Abstract]
  25. "Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins."J. Biol. Chem. 277:4973-4980(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10."Blood 101:729-738(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation."J. Biol. Chem. 278:4770-4777(2003) [PubMed] [Europe PMC] [Abstract]
  28. "Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability."J. Biol. Chem. 278:39583-39590(2003) [PubMed] [Europe PMC] [Abstract]
  29. "betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932."Mol. Cell. Biol. 23:402-413(2003) [PubMed] [Europe PMC] [Abstract]
  30. "Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB."J. Biol. Chem. 279:17819-17825(2004) [PubMed] [Europe PMC] [Abstract]
  31. "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages: involvement in cytokine synthesis."Infect. Immun. 72:2582-2589(2004) [PubMed] [Europe PMC] [Abstract]
  33. "Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105."Mol. Cell. Biol. 24:9658-9667(2004) [PubMed] [Europe PMC] [Abstract]
  34. "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway." Nat. Cell Biol. 6:97-105(2004) [PubMed] [Europe PMC] [Abstract]
  35. "Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)."Proc. Natl. Acad. Sci. U.S.A. 103:14767-14772(2006) [PubMed] [Europe PMC] [Abstract]
  36. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  37. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  38. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  39. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  40. "Structure of the NF-kappa B p50 homodimer bound to DNA."Nature 373:311-317(1995) [PubMed] [Europe PMC] [Abstract]
  41. "Structure of an IkappaBalpha/NF-kappaB complex."Cell 95:749-758(1998) [PubMed] [Europe PMC] [Abstract]
  42. "Solution structure of the death domain in human nuclear factor NF-kappa-B p105 subunit."Submitted (DEC-2006) to the PDB data bank