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Cytokeratin 17 (CK17)

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PC2; KRT17; K17; PC; PCHC1; Keratin 17; Keratin, type I cytoskeletal 17

Cytokeratin 17 (CK17)
CCC B822
HGNC 6427
MGI 96691
PubMed 21549635
RGD 1303181
UniProt Q04695
Wiki KRT17

Keratin 17 is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.The functional KRT17 gene differs from the pseudogenes by the extent of methylation of certain DNA sequences in the 5-prime upstream region. The KRT17 gene encodes a polypeptide of 432 amino acids with a calculated molecular weight of 48,000. Using S1-nuclease protection assays and RNAs from several cell lines, Troyanovsky et al. identified a single transcriptional start point 26 nucleotides downstream from a TATA box element. Synthesis of cytokeratin-17 seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cell.'

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB822Hu01 Recombinant Cytokeratin 17 (CK17) Positive Control; Immunogen; SDS-PAGE; WB.
RPB822Hu02 Recombinant Cytokeratin 17 (CK17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB822Hu01 Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP; FCM
MAB822Hu22 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
LAB822Hu71 Biotin-Linked Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC.
LAB822Hu81 FITC-Linked Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IF.
MAB822Hu21 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu23 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu24 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu25 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
MAB822Hu27 Monoclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
PAB822Hu02 Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
Assay Kits SEB822Hu ELISA Kit for Cytokeratin 17 (CK17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytokeratin 17 (CK17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytokeratin 17 (CK17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytokeratin 17 (CK17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytokeratin 17 (CK17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 17 (CK17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB822Ra01 Recombinant Cytokeratin 17 (CK17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB822Ra01 Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC; IP.
LAB822Ra71 Biotin-Linked Polyclonal Antibody to Cytokeratin 17 (CK17) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cytokeratin 17 (CK17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 17 (CK17) ELISA Kit Customized Service Offer
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  20. "Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2."Br. J. Dermatol. 139:475-480(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2."J. Invest. Dermatol. 113:848-850(1999) [PubMed] [Europe PMC] [Abstract]
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  23. "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."J. Invest. Dermatol. 117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]
  24. "A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2."J. Invest. Dermatol. 118:545-547(2002) [PubMed] [Europe PMC] [Abstract]
  25. "A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2."J. Invest. Dermatol. 122:892-895(2004) [PubMed] [Europe PMC] [Abstract]
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  27. "The genetic basis of pachyonychia congenita."J. Investig. Dermatol. Symp. Proc. 10:21-30(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity."J. Dermatol. 33:161-164(2006) [PubMed] [Europe PMC] [Abstract]
  29. "A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita."J. Dermatol. Sci. 48:199-205(2007) [PubMed] [Europe PMC] [Abstract]
  30. "A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb."Br. J. Dermatol. 159:730-732(2008) [PubMed] [Europe PMC] [Abstract]
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  33. "A novel mutation of keratin 17 gene in a pedigree with pachyonychia congenita type 2."Int. J. Dermatol. 52:117-119(2013) [PubMed] [Europe PMC] [Abstract]
  34. "Novel mutation (p.L91P, c.272T>C) of keratin 17 in a case with pachyonychia congenita type 2."J. Dermatol. 40:757-758(2013) [PubMed] [Europe PMC] [Abstract]