Vitamin D Binding Protein (DBP)

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GC; VDBG; VDBP; Group-Specific Component; Gc-globulin

Vitamin D Binding Protein (DBP)

Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells. Human GC is a glycosylated alpha-globulin, ~58 kDa in size. Its 458 amino acids are coded for by 1690 nucleotides on chromosome 4 (4q11–q13). The primary structure contains 28 cysteine residues forming multiple disulfide bonds. GC contains 3 domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB810Hu01 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB810Hu02 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB810Hu03 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
EPB810Hu61 Eukaryotic Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
APB810Hu61 Active Vitamin D Binding Protein (DBP) Cell culture; Activity Assays.
Antibodies PAB810Hu01 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP; FCM
MAB810Hu22 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB,IHC
LAB810Hu71 Biotin-Linked Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC.
PAB810Hu02 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
PAB810Hu03 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Hu21 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Hu23 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Hu24 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Hu25 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Hu27 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB.
MAB810Hu26 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
Assay Kits SEB810Hu ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB810Hu CLIA Kit for Vitamin D Binding Protein (DBP) Chemiluminescent immunoassay for Antigen Detection.
AEB810Hu ELISA Kit for Anti-Vitamin D Binding Protein Antibody (Anti-DBP) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB810Mu01 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB810Mu02 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB810Mu03 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB810Mu01 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
PAB810Mu02 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
LAB810Mu71 Biotin-Linked Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC.
PAB810Mu03 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
Assay Kits SEB810Mu ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB810Ra01 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB810Ra02 Recombinant Vitamin D Binding Protein (DBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB810Ra01 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
PAB810Ra02 Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
LAB810Ra71 Biotin-Linked Polyclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC.
MAB810Ra22 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Ra21 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Ra23 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
MAB810Ra24 Monoclonal Antibody to Vitamin D Binding Protein (DBP) WB; IHC; ICC; IP.
Assay Kits SEB810Ra ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vitamin D Binding Protein (DBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vitamin D Binding Protein (DBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vitamin D Binding Protein (DBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vitamin D Binding Protein (DBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vitamin D Binding Protein (DBP) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vitamin D Binding Protein (DBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vitamin D Binding Protein (DBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vitamin D Binding Protein (DBP) Polyclonal Antibody Customized Service Offer
Assay Kits SEB810Eq ELISA Kit for Vitamin D Binding Protein (DBP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family."J. Clin. Invest. 76:2420-2424(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Human group-specific component (Gc) is a member of the albumin family."Proc. Natl. Acad. Sci. U.S.A. 82:7994-7998(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence and organization of the human vitamin D-binding protein gene."Biochim. Biophys. Acta 1216:385-394(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family."Genomics 16:751-754(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals."Gene 54:285-290(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein."Biochim. Biophys. Acta 871:189-198(1986) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component)."Biochemistry 18:1611-1617(1979) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of mutants of the vitamin-D-binding protein/group specific component: GC aborigine (1A1) from Australian aborigines and South African blacks, and 2A9 from south Germany."Vox Sang. 68:50-54(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types."Hum. Genet. 89:401-406(1992) [PubMed] [Europe PMC] [Abstract]
  14. "A structural basis for the unique binding features of the human vitamin D-binding protein."Nat. Struct. Biol. 9:131-136(2002) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]