Phospholipid Scramblase 1 (PLSCR1)

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MMTRA1B; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase

Phospholipid Scramblase 1 (PLSCR1)

Scramblases are members of the general family of transmembrane lipid transporters known as flippases. The inner-leaflet facing the inside of the cell contains negatively-charged amino-phospholipids and phosphatidylethanolamine. The outer-leaflet, facing the outside environment, contains phosphatidylcholine and sphingomyelin. Scramblase is an enzyme, present in the cell membrane, that can transport (scramble) the negatively-charged phospholipids from the inner-leaflet to the outer-leaflet, and vice versa.Wiedmer et al. (2000) determined that the PLSCR1 gene contains 9 exons and spans about 30 kb. The first exon is untranslated. By deletion analysis of PLSCR1 promoter-reporter constructs, they found that 97% of the promoter activity resides between -95 bp in the 5-prime flanking region to +60 bp of the first exon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB781Hu01 Recombinant Phospholipid Scramblase 1 (PLSCR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB781Hu02 Recombinant Phospholipid Scramblase 1 (PLSCR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB781Hu03 Recombinant Phospholipid Scramblase 1 (PLSCR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB781Hu04 Recombinant Phospholipid Scramblase 1 (PLSCR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB781Hu01 Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) WB
MAB781Hu22 Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) WB; IHC; ICC; IP.
Assay Kits SEB781Hu ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipid Scramblase 1 (PLSCR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipid Scramblase 1 (PLSCR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids."J. Biol. Chem. 272:18240-18244(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene."Biochem. Biophys. Res. Commun. 249:449-455(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of three new members of the phospholipid scramblase gene family."Biochim. Biophys. Acta 1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid."J. Biol. Chem. 271:17205-17210(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta."J. Biol. Chem. 275:23065-23073(2000) [PubMed] [Europe PMC] [Abstract]
  9. "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1."J. Biol. Chem. 276:28984-28990(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids."Biochemistry 37:6361-6366(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids."Biochemistry 37:2356-2360(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane."Biochemistry 42:1227-1233(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Phospholipid scramblase 1 potentiates the antiviral activity of interferon."J. Virol. 78:8983-8993(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression."J. Biol. Chem. 280:35062-35068(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases."J. Biol. Chem. 289:13206-13218(2014) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha."J. Biol. Chem. 280:10599-10606(2005) [PubMed] [Europe PMC] [Abstract]