Phospholipid Scramblase 1 (PLSCR1)
[Edit]MMTRA1B; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase
Scramblases are members of the general family of transmembrane lipid transporters known as flippases. The inner-leaflet facing the inside of the cell contains negatively-charged amino-phospholipids and phosphatidylethanolamine. The outer-leaflet, facing the outside environment, contains phosphatidylcholine and sphingomyelin. Scramblase is an enzyme, present in the cell membrane, that can transport (scramble) the negatively-charged phospholipids from the inner-leaflet to the outer-leaflet, and vice versa.Wiedmer et al. (2000) determined that the PLSCR1 gene contains 9 exons and spans about 30 kb. The first exon is untranslated. By deletion analysis of PLSCR1 promoter-reporter constructs, they found that 97% of the promoter activity resides between -95 bp in the 5-prime flanking region to +60 bp of the first exon.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB781Hu01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPB781Hu02 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
RPB781Hu03 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
RPB781Hu04 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAB781Hu01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB |
MAB781Hu22 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. | |
Assay Kits | SEB781Hu | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | ELISA Kit Customized Service Offer |
- "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids."J. Biol. Chem. 272:18240-18244(1997) [PubMed] [Europe PMC] [Abstract]
- "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene."Biochem. Biophys. Res. Commun. 249:449-455(1998) [PubMed] [Europe PMC] [Abstract]
- "Identification of three new members of the phospholipid scramblase gene family."Biochim. Biophys. Acta 1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid."J. Biol. Chem. 271:17205-17210(1996) [PubMed] [Europe PMC] [Abstract]
- "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta."J. Biol. Chem. 275:23065-23073(2000) [PubMed] [Europe PMC] [Abstract]
- "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1."J. Biol. Chem. 276:28984-28990(2001) [PubMed] [Europe PMC] [Abstract]
- "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids."Biochemistry 37:6361-6366(1998) [PubMed] [Europe PMC] [Abstract]
- "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids."Biochemistry 37:2356-2360(1998) [PubMed] [Europe PMC] [Abstract]
- "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane."Biochemistry 42:1227-1233(2003) [PubMed] [Europe PMC] [Abstract]
- "Phospholipid scramblase 1 potentiates the antiviral activity of interferon."J. Virol. 78:8983-8993(2004) [PubMed] [Europe PMC] [Abstract]
- "Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression."J. Biol. Chem. 280:35062-35068(2005) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases."J. Biol. Chem. 289:13206-13218(2014) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha."J. Biol. Chem. 280:10599-10606(2005) [PubMed] [Europe PMC] [Abstract]