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CUB Domain Containing Protein 1 (CDCP1)

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CD318; CDCP1; SIMA135; TRASK; Membrane glycoprotein gp140; Transmembrane and associated with src kinases; Subtractive immunization M plus HEp3-associated 135 kDa

CUB Domain Containing Protein 1 (CDCP1)
CCC B779
HGNC 24357
MGI 2442010
PubMed 12799299
RGD 1305578
UniProt Q9H5V8
Wiki CDCP1

CUB domain-containing protein 1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface.

It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported. RT-PCR and Northern blot analysis revealed highest CDCP1 expression in colon and lung adenocarcinomas. Expression was lower in normal colon, lung, testis, esophagus, stomach, rectum, prostate, placenta, and peripheral blood lymphocytes, and no expression was detected in pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB779Hu01 Recombinant CUB Domain Containing Protein 1 (CDCP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB779Hu01 Polyclonal Antibody to CUB Domain Containing Protein 1 (CDCP1) WB; IHC; ICC; IP.
MAB779Hu22 Monoclonal Antibody to CUB Domain Containing Protein 1 (CDCP1) WB; IHC; ICC; IP.
Assay Kits SEB779Hu ELISA Kit for CUB Domain Containing Protein 1 (CDCP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB779Hu CLIA Kit for CUB Domain Containing Protein 1 (CDCP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CUB Domain Containing Protein 1 (CDCP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CUB Domain Containing Protein 1 (CDCP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUB Domain Containing Protein 1 (CDCP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CUB Domain Containing Protein 1 (CDCP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CUB Domain Containing Protein 1 (CDCP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CUB Domain Containing Protein 1 (CDCP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CUB Domain Containing Protein 1 (CDCP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUB Domain Containing Protein 1 (CDCP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CUB Domain Containing Protein 1 (CDCP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CUB Domain Containing Protein 1 (CDCP1) ELISA Kit Customized Service Offer
  1. "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer."Oncogene 20:4402-4408(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen."Oncogene 22:1783-1794(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Adhesion signaling by a novel mitotic substrate of src kinases."Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia."J. Biol. Chem. 279:14772-14783(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein."J. Cell Biol. 132:727-740(1996) [PubMed] [Europe PMC] [Abstract]
  10. "CDCP1 is a novel marker for hematopoietic stem cells."Ann. N. Y. Acad. Sci. 996:222-226(2003) [PubMed] [Europe PMC] [Abstract]
  11. "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin."Stem Cells 22:334-343(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The C2 domain of PKCdelta is a phosphotyrosine binding domain."Cell 121:271-280(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS."Proteomics 6:1437-1449(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells."FEBS Lett. 581:1137-1142(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]