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Bone Marrow Stromal Cell Antigen 2 (BST2)

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CD317; Tetherin; HM1.24 antigen

Bone Marrow Stromal Cell Antigen 2 (BST2)
CCC B777
HGNC 1119
MGI 1916800
PubMed 23221546
RGD 727849
UniProt Q10589
Wiki BST2

  • Tetherin is a type 2 integral membrane protein, with the N-terminus in the cytoplasm, one membrane spanning domain, and a C-terminus modified by the addition of a glycosyl-phosphatidylinositol (gpi) anchor. When the virion buds from the surface of the cell, one of the tetherin membrane domains is in the new viral membrane, the other remains in the plasma membrane, tethering the virion to the cell. It is antagonized by the viral protein Vpu which is thought to work by targetting tetherin for degredation via the beta-TrCP2 dependent pathway.

  • Tetherin exists as a dimer on the surface of cells, and prevention of dimerisation by mutating the cystine residues, prevents tetherin from inhibiting virus release, although it is still detectable in the cell.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB777Hu01 Recombinant Bone Marrow Stromal Cell Antigen 2 (BST2) Positive Control; Immunogen; SDS-PAGE; WB.
EPB777Hu61 Eukaryotic Bone Marrow Stromal Cell Antigen 2 (BST2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB777Hu01 Polyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) WB; IHC; ICC; IP.
MAB777Hu22 Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) WB; IHC; ICC; IP.
Assay Kits SEB777Hu ELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bone Marrow Stromal Cell Antigen 2 (BST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bone Marrow Stromal Cell Antigen 2 (BST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth."Genomics 26:527-534(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells."Biochem. Biophys. Res. Commun. 258:583-591(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry."Cell. Immunol. 236:6-16(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein."Cell Host Microbe 3:245-252(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu."Nature 451:425-430(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Tetherin inhibits HIV-1 release by directly tethering virions to cells."Cell 139:499-511(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A tail of Tetherin: how pandemic HIV-1 conquered the world."Cell Host Microbe 6:393-395(2009) [PubMed] [Europe PMC] [Abstract]
  12. "HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes."J. Biol. Chem. 284:35060-35072(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction."J. Exp. Med. 206:1603-1614(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin."J. Virol. 83:1837-1844(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein."J. Virol. 83:11966-11978(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein."Proc. Natl. Acad. Sci. U.S.A. 106:2886-2891(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu."Retrovirology 6:80-80(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin."J. Virol. 84:10569-10580(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
  22. "The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin."PLoS Pathog. 6:E1000843-E1000843(2010) [PubMed] [Europe PMC] [Abstract]
  23. "BST-2/tetherin: a new component of the innate immune response to enveloped viruses."Trends Microbiol. 18:388-396(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "structural basis for the antiviral activity of Bst-2/tetherin and its viral antagonism."Front. Microbiol. 2:250-250(2011) [PubMed] [Europe PMC] [Abstract]
  26. "The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?"J. Interferon Cytokine Res. 31:137-144(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Tetherin and its viral antagonists."J. Neuroimmun. Pharmacol. 6:188-201(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Tetherin inhibits prototypic foamy virus release."Virol. J. 8:198-198(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin."Virology 417:50-56(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction."Viruses 3:520-540(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Vpu and BST2: still not there yet?"Front. Microbiol. 3:131-131(2012) [PubMed] [Europe PMC] [Abstract]
  32. "BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity."J. Cell. Biochem. 113:1013-1021(2012) [PubMed] [Europe PMC] [Abstract]
  33. "Restriction of retroviral replication by tetherin/BST-2."Mol. Biol. Int. 2012:424768-424768(2012) [PubMed] [Europe PMC] [Abstract]
  34. "Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities."PLoS Pathog. 8:E1002931-E1002931(2012) [PubMed] [Europe PMC] [Abstract]
  35. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  36. "Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin."Virology 428:98-111(2012) [PubMed] [Europe PMC] [Abstract]
  37. "Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain."Cell Host Microbe 7:314-323(2010) [PubMed] [Europe PMC] [Abstract]
  38. "Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations."Proc. Natl. Acad. Sci. U.S.A. 107:17951-17956(2010) [PubMed] [Europe PMC] [Abstract]
  39. "Structural insight into the mechanisms of enveloped virus tethering by tetherin."Proc. Natl. Acad. Sci. U.S.A. 107:18428-18432(2010) [PubMed] [Europe PMC] [Abstract]