Minichromosome Maintenance Deficient 2 (MCM2)
[Edit]BM28; CCNL1; CDCL1; Cdc19; Mitotin; DNA Replication Licensing Factor MCM2; Nuclear protein BM28
![Minichromosome Maintenance Deficient 2 (MCM2)](/upload/item/img/Minichromosome-Maintenance-Deficient-2-(MCM2)-91768.jpg)
DNA replication licensing factor MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.
This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB768Hu01 | Recombinant Minichromosome Maintenance Deficient 2 (MCM2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB768Hu01 | Polyclonal Antibody to Minichromosome Maintenance Deficient 2 (MCM2) | WB; IHC; ICC; IP. |
MAB768Hu22 | Monoclonal Antibody to Minichromosome Maintenance Deficient 2 (MCM2) | WB; IHC; ICC; IP. | |
Assay Kits | SEB768Hu | ELISA Kit for Minichromosome Maintenance Deficient 2 (MCM2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Minichromosome Maintenance Deficient 2 (MCM2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Minichromosome Maintenance Deficient 2 (MCM2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Minichromosome Maintenance Deficient 2 (MCM2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Minichromosome Maintenance Deficient 2 (MCM2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Minichromosome Maintenance Deficient 2 (MCM2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Minichromosome Maintenance Deficient 2 (MCM2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Minichromosome Maintenance Deficient 2 (MCM2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Minichromosome Maintenance Deficient 2 (MCM2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Minichromosome Maintenance Deficient 2 (MCM2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Minichromosome Maintenance Deficient 2 (MCM2) | ELISA Kit Customized Service Offer |
- "A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division."J. Cell Sci. 107:253-265(1994) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21."Cytogenet. Cell Genet. 65:276-277(1994) [PubMed] [Europe PMC] [Abstract]
- "A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex."J. Biol. Chem. 272:24508-24513(1997) [PubMed] [Europe PMC] [Abstract]
- "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase."Nucleic Acids Res. 28:4769-4777(2000) [PubMed] [Europe PMC] [Abstract]
- "Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases."Proc. Natl. Acad. Sci. U.S.A. 101:10078-10083(2004) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells."Mol. Biol. Cell 17:4459-4472(2006) [PubMed] [Europe PMC] [Abstract]
- "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
- "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
- "Cdc7 is an active kinase in human cancer cells undergoing replication stress."J. Biol. Chem. 282:208-215(2007) [PubMed] [Europe PMC] [Abstract]
- "Identification and characterization of a novel component of the human minichromosome maintenance complex."Mol. Cell. Biol. 27:3044-3055(2007) [PubMed] [Europe PMC] [Abstract]
- "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
- "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
- "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
- "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]