Glutamate Receptor Interacting Protein 1 (GRIP1)

In situ hybridization of embryonic day 17 (E17) rat embryos showed that Grip1 is expressed relatively homogeneously and strongly throughout most regions of the nervous system. Grip1 was expressed at very low levels in many nonneuronal tissues of E17 rat, with the highest levels found in nasal cavities and major blood vessels. Coimmunoprecipitation analysis demonstrated that Grip1 and Efnb1 interact in E14 mouse embryos.

Bruckner et al. (1999) found that GRIP1 is recruited into rafts through association with EFNB1. In addition, a GRIP1-associated serine/threonine kinase activity was recruited into EFNB1/GRIP1 complexes. Bruckner et al. (1999) suggested that GRIP proteins provide a scaffold for the assembly of a multiprotein signaling complex downstream of ephrin B ligands.