≡

Signal Transducer And Activator Of Transcription 1 (STAT1)

[Edit]

ISGF-3; STAT91; Transcription Factor ISGF-3 Components p91/p84

Signal Transducer And Activator Of Transcription 1 (STAT1)
CCC B740
HGNC 11362
MGI 103063
PubMed 11493533
RGD 3771
UniProt P42224
Wiki STAT1

STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I or type II interferons.

In response to IFN-gamma; stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB740Hu01 Recombinant Signal Transducer And Activator Of Transcription 1 (STAT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB740Hu02 Recombinant Signal Transducer And Activator Of Transcription 1 (STAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB740Hu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 1 (STAT1) WB; IHC; ICC; IP.
PAB740Hu02 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 1 (STAT1) WB; IHC; ICC; IP.
Assay Kits SEB740Mi ELISA Kit for Signal Transducer And Activator Of Transcription 1 (STAT1) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB740Hu ELISA Kit for Signal Transducer And Activator Of Transcription 1 (STAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB740Mu01 Recombinant Signal Transducer And Activator Of Transcription 1 (STAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB740Mu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 1 (STAT1) WB; IHC; ICC; IP.
Assay Kits SEB740Mi ELISA Kit for Signal Transducer And Activator Of Transcription 1 (STAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Transducer And Activator Of Transcription 1 (STAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Transducer And Activator Of Transcription 1 (STAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Transducer And Activator Of Transcription 1 (STAT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEB740Mi ELISA Kit for Signal Transducer And Activator Of Transcription 1 (STAT1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha."Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2."Nucleic Acids Res. 23:459-463(1995) [PubMed] [Europe PMC] [Abstract]
  7. "A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)."Cell 70:323-335(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation."Cell 82:241-250(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor."J. Biol. Chem. 270:20775-20780(1995) [PubMed] [Europe PMC] [Abstract]
  10. "The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals."EMBO J. 15:1075-1084(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling."Mol. Cell. Biol. 17:2048-2056(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Inhibition of Stat1-mediated gene activation by PIAS1."Proc. Natl. Acad. Sci. U.S.A. 95:10626-10631(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Viral inhibition of interferon signal transduction."Intervirology 42:325-330(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Sendai virus C protein physically associates with Stat1."Genes Cells 6:545-557(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion."J. Biol. Chem. 276:19512-19523(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a nuclear Stat1 protein tyrosine phosphatase."Mol. Cell. Biol. 22:5662-5668(2002) [PubMed] [Europe PMC] [Abstract]
  17. "PIAS proteins promote SUMO-1 conjugation to STAT1."Blood 102:3311-3313(2003) [PubMed] [Europe PMC] [Abstract]
  18. "SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation."J. Biol. Chem. 278:30091-30097(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Signal transduction via the stem cell factor receptor/c-Kit."Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Protein kinase Cdelta regulates apoptosis via activation of STAT1."J. Biol. Chem. 279:45603-45612(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."Biochem. Biophys. Res. Commun. 336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Hepatitis C virus expression suppresses interferon signaling by degrading STAT1."Gastroenterology 128:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1."Bone 41:273-281(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus."J. Cell. Physiol. 212:148-156(2007) [PubMed] [Europe PMC] [Abstract]
  25. "MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1."Biochem. J. 409:179-185(2008) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties."Chem. Biol. 15:808-817(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage."PLoS ONE 3:E3961-E3961(2008) [PubMed] [Europe PMC] [Abstract]
  29. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  30. "PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling."Genes Dev. 23:118-132(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  33. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  34. "Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection."J. Biol. Chem. 286:44412-44423(2011) [PubMed] [Europe PMC] [Abstract]
  36. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  37. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  38. "Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA."Cell 93:827-839(1998) [PubMed] [Europe PMC] [Abstract]
  39. "Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation."Science 293:300-303(2001) [PubMed] [Europe PMC] [Abstract]
  40. "Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency."Nat. Genet. 33:388-391(2003) [PubMed] [Europe PMC] [Abstract]
  41. "Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively."J. Virol. 78:5633-5641(2004) [PubMed] [Europe PMC] [Abstract]
  42. "Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease." PLoS Genet. 2:E131-E131(2006) [PubMed] [Europe PMC] [Abstract]
  43. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  44. "A novel form of human STAT1 deficiency impairing early but not late responses to interferons."Blood 116:5895-5906(2010) [PubMed] [Europe PMC] [Abstract]
  45. "Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis." J. Exp. Med. 208:1635-1648(2011) [PubMed] [Europe PMC] [Abstract]
  46. "STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis."N. Engl. J. Med. 365:54-61(2011) [PubMed] [Europe PMC] [Abstract]
  47. "Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease." Hum. Mutat. 33:1377-1387(2012) [PubMed] [Europe PMC] [Abstract]