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Signal Transducer And Activator Of Transcription 5B (STAT5B)

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STAT5-B

Signal Transducer And Activator Of Transcription 5B (STAT5B)
CCC B727
HGNC 11367
MGI 103035
PubMed 12429742
RGD 3774
UniProt P51692
Wiki STAT5B

Signal transducer and activator of transcription 5B is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB727Hu01 Recombinant Signal Transducer And Activator Of Transcription 5B (STAT5B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB727Hu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 5B (STAT5B) WB,ICC/IF
Assay Kits SEB727Mi ELISA Kit for Signal Transducer And Activator Of Transcription 5B (STAT5B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Transducer And Activator Of Transcription 5B (STAT5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Transducer And Activator Of Transcription 5B (STAT5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Transducer And Activator Of Transcription 5B (STAT5B) Polyclonal Antibody Customized Service Offer
Assay Kits SEB727Mi ELISA Kit for Signal Transducer And Activator Of Transcription 5B (STAT5B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Transducer And Activator Of Transcription 5B (STAT5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Transducer And Activator Of Transcription 5B (STAT5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Transducer And Activator Of Transcription 5B (STAT5B) Polyclonal Antibody Customized Service Offer
Assay Kits SEB727Mi ELISA Kit for Signal Transducer And Activator Of Transcription 5B (STAT5B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Transducer And Activator Of Transcription 5B (STAT5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Transducer And Activator Of Transcription 5B (STAT5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Transducer And Activator Of Transcription 5B (STAT5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Transducer And Activator Of Transcription 5B (STAT5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducer And Activator Of Transcription 5B (STAT5B) ELISA Kit Customized Service Offer
  1. "Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone."Mol. Endocrinol. 10:508-518(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells."J. Biol. Chem. 271:10738-10744(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter."Gene 285:311-318(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of Stat 5B as a substrate of the insulin receptor."Eur. J. Biochem. 250:411-417(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling."Cell 96:121-130(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells."EMBO J. 21:5766-5774(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus."Mol. Endocrinol. 16:58-69(2002) [PubMed] [Europe PMC] [Abstract]
  9. "NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain."J. Biol. Chem. 278:45340-45351(2003) [PubMed] [Europe PMC] [Abstract]
  10. "FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy."Blood 103:1085-1088(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Signal transduction via the stem cell factor receptor/c-Kit."Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta."Mol. Cell. Biol. 24:4557-4570(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation."J. Biol. Chem. 280:13817-13823(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b."J. Clin. Endocrinol. Metab. 90:4260-4266(2005) [PubMed] [Europe PMC] [Abstract]
  15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6."Breast Cancer Res. 9:R79-R79(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Growth hormone insensitivity associated with a STAT5b mutation."N. Engl. J. Med. 349:1139-1147(2003) [PubMed] [Europe PMC] [Abstract]
  24. "A Novel Missense Mutation in the SH2 Domain of the STAT5B Gene Results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease."J. Clin. Endocrinol. Metab. 97:E830-839(2012) [PubMed] [Europe PMC] [Abstract]