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Protein Kinase B Beta (PKBb)

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AKT2; PKBBETA; PRKB-B; RAC-BETA; RAC-Beta Serine/Threonine-Protein Kinase; V-Akt Murine Thymoma Viral Oncogene Homolog 2

Protein Kinase B Beta (PKBb)
CCC B719
HGNC 392
MGI 104874
PubMed 12517798
RGD 2082
UniProt P31751
Wiki AKT

AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phosphorylating several known proteins. Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initaited by the large T antigen as well as the neu oncogene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB719Hu01 Recombinant Protein Kinase B Beta (PKBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB719Hu01 Polyclonal Antibody to Protein Kinase B Beta (PKBb) WB; IHC; ICC/IF
MAB719Hu22 Monoclonal Antibody to Protein Kinase B Beta (PKBb) WB; IHC; ICC; IP.
Assay Kits SEB719Hu ELISA Kit for Protein Kinase B Beta (PKBb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase B Beta (PKBb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase B Beta (PKBb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase B Beta (PKBb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase B Beta (PKBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase B Beta (PKBb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB719Ra01 Recombinant Protein Kinase B Beta (PKBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB719Ra01 Polyclonal Antibody to Protein Kinase B Beta (PKBb) WB; IHC; ICC; IP.
MAB719Ra21 Monoclonal Antibody to Protein Kinase B Beta (PKBb) WB; IHC; ICC; IP.
Assay Kits SEB719Ra ELISA Kit for Protein Kinase B Beta (PKBb) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of a second form of rac protein kinase."Cell Regul. 2:1001-1009(1991) [PubMed] [Europe PMC] [Abstract]
  2. "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas."Proc. Natl. Acad. Sci. U.S.A. 89:9267-9271(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha."Biochem. J. 331:299-308(1998) [PubMed] [Europe PMC] [Abstract]
  7. "The protooncogene TCL1 is an Akt kinase coactivator."Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Activation of a GST-tagged AKT2/PKBbeta."Biochim. Biophys. Acta 1725:340-347(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Kinetic mechanism of AKT/PKB enzyme family."J. Biol. Chem. 281:13949-13956(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA."J. Cell. Physiol. 214:158-165(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt."Dev. Cell 17:800-810(2009) [PubMed] [Europe PMC] [Abstract]
  13. "ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization."Mol. Cell. Biol. 29:1459-1471(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "The E3 ligase TRAF6 regulates Akt ubiquitination and activation."Science 325:1134-1138(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Akt2 and Akt3 play a pivotal role in malignant gliomas."Neuro-oncol. 12:221-232(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Akt signalling in health and disease."Cell. Signal. 23:1515-1527(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Akt1 and Akt2: differentiating the aktion."Histol. Histopathol. 26:651-662(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2)."Mol. Biol. Cell 22:2946-2956(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation."Mol. Cell 9:1227-1240(2002) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP."Nat. Struct. Biol. 9:940-944(2002) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of an inactive Akt2 kinase domain."Structure 11:21-30(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates."J. Biomol. NMR 28:137-155(2004) [PubMed] [Europe PMC] [Abstract]
  27. "A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera."J. Mol. Biol. 367:882-894(2007) [PubMed] [Europe PMC] [Abstract]
  28. "Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase." J. Med. Chem. 51:5663-5679(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Aminofurazans as potent inhibitors of AKT kinase."Bioorg. Med. Chem. Lett. 19:1508-1511(2009) [PubMed] [Europe PMC] [Abstract]
  30. "A family with severe insulin resistance and diabetes due to a mutation in AKT2."Science 304:1325-1328(2004) [PubMed] [Europe PMC] [Abstract]
  31. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  32. "Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis."J. Clin. Invest. 119:315-322(2009) [PubMed] [Europe PMC] [Abstract]
  33. "An activating mutation of AKT2 and human hypoglycemia."Science 334:474-474(2011) [PubMed] [Europe PMC] [Abstract]