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Kruppel Like Factor 5, Intestinal (KLF5)

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KLF5; BTEB2; CKLF; IKLF; Intestinal Enriched Krüppel-Like Factor; Colon krueppel-like factor; Basic Transcription Element Binding Protein 2; GC-box-binding protein 2

Kruppel Like Factor 5, Intestinal (KLF5)
CCC B712
HGNC 6349
MGI 1338056
PubMed 16054042
RGD 621446
UniProt Q13887
Wiki KLF5

  • Krueppel-like factor 5 is a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.

  • Klf5, also known as (IKLF) or  (Bteb2) has been assigned purely transcriptional activation activity (Fig. 1A) but, similar to Klf4, binds p300 which acetylates the first zinc finger conferring a trans-activating function. Importantly for Klf4 & Klf5, the amino acids that are predicted by the Klevit model to interact with DNA are identical (Fig. 1B and Fig. 2) and the two compete for the same CACCC element found in a wide variety of promoters.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB712Hu01 Recombinant Kruppel Like Factor 5, Intestinal (KLF5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB712Hu01 Polyclonal Antibody to Kruppel Like Factor 5, Intestinal (KLF5) WB; IHC; ICC; IP.
MAB712Hu22 Monoclonal Antibody to Kruppel Like Factor 5, Intestinal (KLF5) WB; IHC; ICC; IP.
Assay Kits SEB712Hu ELISA Kit for Kruppel Like Factor 5, Intestinal (KLF5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kruppel Like Factor 5, Intestinal (KLF5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kruppel Like Factor 5, Intestinal (KLF5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kruppel Like Factor 5, Intestinal (KLF5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kruppel Like Factor 5, Intestinal (KLF5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 5, Intestinal (KLF5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kruppel Like Factor 5, Intestinal (KLF5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kruppel Like Factor 5, Intestinal (KLF5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kruppel Like Factor 5, Intestinal (KLF5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kruppel Like Factor 5, Intestinal (KLF5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 5, Intestinal (KLF5) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter."Nucleic Acids Res. 27:4807-4815(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2."Nucleic Acids Res. 21:1527-1532(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells."Oncogene 24:3319-3327(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of three tandem repeats of ZF-C2H2 domains from human kruppel-like factor 5."Submitted (FEB-2008) to the PDB data bank
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]