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TATA Binding Protein (TBP)

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GTF2D; GTF2D1; SCA17; TFIID; TATA sequence-binding protein; TATA-box factor; Transcription initiation factor TFIID TBP subunit

TATA Binding Protein (TBP)
CCC B703
HGNC 11588
MGI 101838
PubMed 15916858
RGD 67398
UniProt P20226
Wiki TBP

The TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex.

As one of the few proteins in the preinitiation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. However, it is estimated that only 10-20% of human promoters have TATA boxes. Therefore, TBP is probably not the only protein involved in positioning RNA polymerase II.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB703Hu01 Recombinant TATA Binding Protein (TBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB703Hu21 Monoclonal Antibody to TATA Binding Protein (TBP) WB
MAB703Hu22 Monoclonal Antibody to TATA Binding Protein (TBP) WB
MAB703Hu23 Monoclonal Antibody to TATA Binding Protein (TBP) WB
MAB703Hu24 Monoclonal Antibody to TATA Binding Protein (TBP) WB; ICC/IF
MAB703Hu25 Monoclonal Antibody to TATA Binding Protein (TBP) WB
MAB703Hu27 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu29 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu26 Monoclonal Antibody to TATA Binding Protein (TBP) WB
MAB703Hu28 Monoclonal Antibody to TATA Binding Protein (TBP) WB
Assay Kits n/a CLIA Kit for TATA Binding Protein (TBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Binding Protein (TBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB703Mu01 Recombinant TATA Binding Protein (TBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB703Mu01 Polyclonal Antibody to TATA Binding Protein (TBP) WB
Assay Kits n/a CLIA Kit for TATA Binding Protein (TBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Binding Protein (TBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TATA Binding Protein (TBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TATA Binding Protein (TBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TATA Binding Protein (TBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TATA Binding Protein (TBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Binding Protein (TBP) ELISA Kit Customized Service Offer
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  2. "Functional domains and upstream activation properties of cloned human TATA binding protein."Science 248:1625-1630(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of a transcriptionally active human TATA binding factor."Science 248:1646-1650(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB."J. Virol. 67:4676-4687(1993) [PubMed] [Europe PMC] [Abstract]
  7. "The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein."J. Biol. Chem. 269:30140-30146(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Direct interaction of human TFIID with the HIV-1 transactivator tat."Nature 367:295-299(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits."Science 266:1966-1972(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo."J. Mol. Biol. 250:169-180(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity."J. Biol. Chem. 273:25840-25849(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Requirement of RSF and FACT for transcription of chromatin templates in vitro."Science 282:1900-1904(1998) [PubMed] [Europe PMC] [Abstract]
  13. "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Genomics, evolution, and expression of TBPL2, a member of the TBP family." DNA Cell Biol. 26:369-385(2007) [PubMed] [Europe PMC] [Abstract]
  15. "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."J. Biol. Chem. 274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]
  16. "A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)."Oncogene 18:3682-3695(1999) [PubMed] [Europe PMC] [Abstract]
  18. "BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein."J. Biol. Chem. 276:43056-43064(2001) [PubMed] [Europe PMC] [Abstract]
  19. "The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger."Mol. Cell. Biol. 21:5109-5121(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis."Hum. Mol. Genet. 11:2341-2346(2002) [PubMed] [Europe PMC] [Abstract]
  21. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
  22. "HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs."PLoS Biol. 3:221-230(2005) [PubMed] [Europe PMC] [Abstract]
  23. "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity."J. Biol. Chem. 284:5165-5174(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of a human TATA box-binding protein/TATA element complex."Proc. Natl. Acad. Sci. U.S.A. 93:4862-4867(1996) [PubMed] [Europe PMC] [Abstract]
  26. "How proteins recognize the TATA box."J. Mol. Biol. 261:239-254(1996) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis of preinitiation complex assembly on human pol II promoters."EMBO J. 19:25-36(2000) [PubMed] [Europe PMC] [Abstract]
  28. "Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex."Cell 106:71-81(2001) [PubMed] [Europe PMC] [Abstract]
  29. "A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?"Hum. Mol. Genet. 8:2047-2053(1999) [PubMed] [Europe PMC] [Abstract]
  30. "Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia."Eur. J. Hum. Genet. 9:160-164(2001) [PubMed] [Europe PMC] [Abstract]
  31. "SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein."Hum. Mol. Genet. 10:1441-1448(2001) [PubMed] [Europe PMC] [Abstract]
  32. "Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus." Arch. Neurol. 59:623-629(2002) [PubMed] [Europe PMC] [Abstract]