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TATA Binding Protein (TBP)

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GTF2D; GTF2D1; SCA17; TFIID; TATA sequence-binding protein; TATA-box factor; Transcription initiation factor TFIID TBP subunit

TATA Binding Protein (TBP)
CCC B703
HGNC 11588
MGI 101838
PubMed 15916858
RGD 67398
UniProt P20226
Wiki TBP

The TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex.

As one of the few proteins in the preinitiation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. However, it is estimated that only 10-20% of human promoters have TATA boxes. Therefore, TBP is probably not the only protein involved in positioning RNA polymerase II.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB703Hu01 Recombinant TATA Binding Protein (TBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB703Hu21 Monoclonal Antibody to TATA Binding Protein (TBP) WB
MAB703Hu22 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu23 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu24 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu25 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu27 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu29 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
MAB703Hu26 Monoclonal Antibody to TATA Binding Protein (TBP) WB
MAB703Hu28 Monoclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TATA Binding Protein (TBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Binding Protein (TBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB703Mu01 Recombinant TATA Binding Protein (TBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB703Mu01 Polyclonal Antibody to TATA Binding Protein (TBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TATA Binding Protein (TBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Binding Protein (TBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TATA Binding Protein (TBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TATA Binding Protein (TBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TATA Binding Protein (TBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TATA Binding Protein (TBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TATA Binding Protein (TBP) ELISA Kit Customized Service Offer
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  2. "Functional domains and upstream activation properties of cloned human TATA binding protein."Science 248:1625-1630(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of a transcriptionally active human TATA binding factor."Science 248:1646-1650(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB."J. Virol. 67:4676-4687(1993) [PubMed] [Europe PMC] [Abstract]
  7. "The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein."J. Biol. Chem. 269:30140-30146(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Direct interaction of human TFIID with the HIV-1 transactivator tat."Nature 367:295-299(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits."Science 266:1966-1972(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo."J. Mol. Biol. 250:169-180(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity."J. Biol. Chem. 273:25840-25849(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Requirement of RSF and FACT for transcription of chromatin templates in vitro."Science 282:1900-1904(1998) [PubMed] [Europe PMC] [Abstract]
  13. "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Genomics, evolution, and expression of TBPL2, a member of the TBP family." DNA Cell Biol. 26:369-385(2007) [PubMed] [Europe PMC] [Abstract]
  15. "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."J. Biol. Chem. 274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]
  16. "A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)."Oncogene 18:3682-3695(1999) [PubMed] [Europe PMC] [Abstract]
  18. "BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein."J. Biol. Chem. 276:43056-43064(2001) [PubMed] [Europe PMC] [Abstract]
  19. "The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger."Mol. Cell. Biol. 21:5109-5121(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis."Hum. Mol. Genet. 11:2341-2346(2002) [PubMed] [Europe PMC] [Abstract]
  21. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
  22. "HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs."PLoS Biol. 3:221-230(2005) [PubMed] [Europe PMC] [Abstract]
  23. "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity."J. Biol. Chem. 284:5165-5174(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of a human TATA box-binding protein/TATA element complex."Proc. Natl. Acad. Sci. U.S.A. 93:4862-4867(1996) [PubMed] [Europe PMC] [Abstract]
  26. "How proteins recognize the TATA box."J. Mol. Biol. 261:239-254(1996) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis of preinitiation complex assembly on human pol II promoters."EMBO J. 19:25-36(2000) [PubMed] [Europe PMC] [Abstract]
  28. "Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex."Cell 106:71-81(2001) [PubMed] [Europe PMC] [Abstract]
  29. "A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?"Hum. Mol. Genet. 8:2047-2053(1999) [PubMed] [Europe PMC] [Abstract]
  30. "Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia."Eur. J. Hum. Genet. 9:160-164(2001) [PubMed] [Europe PMC] [Abstract]
  31. "SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein."Hum. Mol. Genet. 10:1441-1448(2001) [PubMed] [Europe PMC] [Abstract]
  32. "Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus." Arch. Neurol. 59:623-629(2002) [PubMed] [Europe PMC] [Abstract]