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Myogenic Differentiation (MyoD)

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MYOD1; PUM; MYF3; bHLHc1; Myoblast Determination Protein 1; Myogenic Factor 3; Class C basic helix-loop-helix protein 1

Myogenic Differentiation (MyoD)
CCC B692
HGNC 7611
MGI 97275
PubMed 10383802
RGD 631429
UniProt P15172
Wiki MyoD

MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 (Myf6).
MYOD is directly acetylated by PCAF at evolutionarily conserved lysines. Acetylated MYOD displayed an increased affinity for its DNA target. Conservative substitutions of acetylated lysines with nonacetylatable arginines impaired the ability of MYOD to stimulate transcription and to induce conversion, indicating that acetylation of MYOD is functionally critical. MYOD mRNA was also downregulated by TNF and IFNG expression in mouse muscle in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB692Hu01 Recombinant Myogenic Differentiation (MyoD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB692Hu02 Recombinant Myogenic Differentiation (MyoD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB692Hu03 Recombinant Myogenic Differentiation (MyoD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB692Hu04 Recombinant Myogenic Differentiation (MyoD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB692Hu01 Polyclonal Antibody to Myogenic Differentiation (MyoD) WB; IHC; ICC; IP.
MAB692Hu22 Monoclonal Antibody to Myogenic Differentiation (MyoD) WB; IHC; ICC; IP.
Assay Kits SEB692Hu ELISA Kit for Myogenic Differentiation (MyoD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myogenic Differentiation (MyoD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myogenic Differentiation (MyoD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myogenic Differentiation (MyoD) Polyclonal Antibody Customized Service Offer
Assay Kits SEB692Mu ELISA Kit for Myogenic Differentiation (MyoD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB692Ra01 Recombinant Myogenic Differentiation (MyoD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB692Ra01 Polyclonal Antibody to Myogenic Differentiation (MyoD) WB; IHC; ICC; IP.
MAB692Ra21 Monoclonal Antibody to Myogenic Differentiation (MyoD) WB; IHC; ICC; IP.
Assay Kits SEB692Ra ELISA Kit for Myogenic Differentiation (MyoD) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human MyoD: cDNA and deduced amino acid sequence."Nucleic Acids Res. 19:1148-1148(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Methylation alterations of the MyoD1 upstream region are predictive of subclassification of human rhabdomyosarcomas."Am. J. Pathol. 152:1071-1079(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products."EMBO J. 8:3617-3625(1989) [PubMed] [Europe PMC] [Abstract]
  5. "A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein."EMBO J. 17:5964-5973(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Control of muscle development by dueling HATs and HDACs."Curr. Opin. Genet. Dev. 11:497-504(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Activation of MyoD-dependent transcription by cdk9/cyclin T2."Oncogene 21:4137-4148(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation."EMBO J. 25:3323-3334(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation."Proc. Natl. Acad. Sci. U.S.A. 109:841-846(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]