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Immunoglobulin G2 (IgG2)

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IGHG2; Ig Gamma-2 Chain C Region; Immunoglobulin Heavy Constant Gamma 2; G2m Marker; Immunoglobulin Gm2

Immunoglobulin G2 (IgG2)
CCC B682
HGNC 5526
UniProt P01859

Oxelius et al. (1981) pointed out that deficiency of IgG2 in combination with IgA deficiency is a critical factor in whether or not IgA-deficient persons have illness (frequent infections, autoimmune disorders, atopy, malabsorption). No allotypes are known on gamma-4 or on gamma-2. The reason may be the test system. Anti-D antiserum is used and this antibody is usually gamma-1 or gamma-3. Patients with IgG2 deficiency have recurrent sinopulmonary infections caused by Pneumococcus and Hemophilus. Tashita et al. (1998) studied 2 Japanese brothers, ages 5 and 10 years and found that both brothers were homozygous for a 1-bp insertion (1793insG) in exon 4 of the IGHG2 gene, just upstream from the alternative splice site for M exons . IgG2 23%; no Crosses placenta easily; third highest Complement activator; extremely low affinity Binds to Fc receptor on phagocytic cells

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB682Hu01 Native Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB682Hu01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB682Hu01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
MAB682Hu22 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
LAB682Hu71 Biotin-Linked Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC.
LAB682Hu81 FITC-Linked Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IF.
Assay Kits CEB682Hu ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB682Gu01 Native Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB682Gu01 Recombinant Immunoglobulin G2 (IgG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB682Gu01 Polyclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
MAB682Gu21 Monoclonal Antibody to Immunoglobulin G2 (IgG2) WB; IHC; ICC; IP.
Assay Kits CEB682Gu ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin G2 (IgG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin G2 (IgG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin G2 (IgG2) Polyclonal Antibody Customized Service Offer
Assay Kits CEB682Bo ELISA Kit for Immunoglobulin G2 (IgG2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. , Submitted (MAR-1980) to the PIR data bank
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