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Melanotransferrin (MFI2)

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CD228; MAP97; MTF1; Antigen P97(Melanoma Associated); Membrane-Bound Transferrin-Like Protein

Melanotransferrin (MFI2)
CCC B677
HGNC 7037
MGI 1353421
PubMed 21933697
RGD 1308155
UniProt P08582
Wiki CD228

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. P97 is a 97,000 molecular weight cell-surface glycoprotein found in human melanomas. Amino acid sequence and iron-binding properties are similar to those of transferrin, lactotransferrin and ovotransferrin; together these constitute a superfamily.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB677Hu01 Recombinant Melanotransferrin (MFI2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB677Hu01 Polyclonal Antibody to Melanotransferrin (MFI2) WB; IHC; ICC; IP.
MAB677Hu22 Monoclonal Antibody to Melanotransferrin (MFI2) WB; IHC; ICC; IP.
Assay Kits SEB677Hu ELISA Kit for Melanotransferrin (MFI2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB677Mu01 Recombinant Melanotransferrin (MFI2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Melanotransferrin (MFI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanotransferrin (MFI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melanotransferrin (MFI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melanotransferrin (MFI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melanotransferrin (MFI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melanotransferrin (MFI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanotransferrin (MFI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melanotransferrin (MFI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melanotransferrin (MFI2) ELISA Kit Customized Service Offer
  1. "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence."Proc. Natl. Acad. Sci. U.S.A. 83:1261-1265(1986) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97."J. Exp. Med. 169:585-590(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein."J. Biol. Chem. 269:3034-3040(1994) [PubMed] [Europe PMC] [Abstract]
  6. "A novel iron uptake mechanism mediated by GPI-anchored human p97."EMBO J. 14:4178-4186(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Human melanotransferrin (p97) has only one functional iron-binding site."FEBS Lett. 298:215-218(1992) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function."FEBS Lett. 305:55-61(1992) [PubMed] [Europe PMC] [Abstract]