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Complement Component 1, S Subcomponent (C1s)

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C1 esterase

Complement Component 1, S Subcomponent (C1s)
CCC B674
HGNC 1247
MGI 1355312
PubMed 23592783
UniProt P09871
Wiki C1s

Complement component 1S is a protein involved in the complement system.C1s cleaves C4, which eventually leads to the production of the C4b-C2a form of C3-convertase.MacKinnon et al. (1987) derived the complete amino acid sequence of C1s from molecular cloning of cDNA. Tosi et al. (1987) presented the complete cDNA sequence of C1s.

Kusumoto et al. (1988) found that the amino acid sequence of C1s was 40.5% identical to that of C1r, with excellent matches of tentative disulfide bond locations conserving the overall domain structure of C1r. In a 27-month-old girl with multiple autoimmune diseases, Dragon-Durey et al. (2001) detected selective C1S deficiency resulting from a nonsense mutation in exon 12 of the C1S gene .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB674Hu01 Recombinant Complement Component 1, S Subcomponent (C1s) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB674Hu01 Polyclonal Antibody to Complement Component 1, S Subcomponent (C1s) WB; IHC; ICC; IP.
MAB674Hu22 Monoclonal Antibody to Complement Component 1, S Subcomponent (C1s) WB; IHC; ICC; IP.
MAB674Hu21 Monoclonal Antibody to Complement Component 1, S Subcomponent (C1s) WB;ICC/IF
MAB674Hu24 Monoclonal Antibody to Complement Component 1, S Subcomponent (C1s) WB; IHC; ICC; IP.
MAB674Hu23 Monoclonal Antibody to Complement Component 1, S Subcomponent (C1s) WB; ICC/IF
MAB674Hu25 Monoclonal Antibody to Complement Component 1, S Subcomponent (C1s) WB
Assay Kits SEB674Hu ELISA Kit for Complement Component 1, S Subcomponent (C1s) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB674Hu CLIA Kit for Complement Component 1, S Subcomponent (C1s) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Component 1, S Subcomponent (C1s) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Component 1, S Subcomponent (C1s) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 1, S Subcomponent (C1s) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 1, S Subcomponent (C1s) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 1, S Subcomponent (C1s) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPB674Ra61 Eukaryotic Complement Component 1, S Subcomponent (C1s) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Complement Component 1, S Subcomponent (C1s) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Component 1, S Subcomponent (C1s) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Component 1, S Subcomponent (C1s) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 1, S Subcomponent (C1s) ELISA Kit Customized Service Offer
  1. "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence."Eur. J. Biochem. 169:547-553(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr."Biochemistry 26:8516-8524(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Human genes for complement components C1r and C1s in a close tail-to-tail arrangement."Proc. Natl. Acad. Sci. U.S.A. 85:7307-7311(1988) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates."J. Immunol. 161:4924-4930(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin."J. Mol. Biol. 208:709-714(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation."Eur. J. Biochem. 156:49-57(1986) [PubMed] [Europe PMC] [Abstract]
  8. "The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments."Biochem. J. 215:565-571(1983) [PubMed] [Europe PMC] [Abstract]
  9. "Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region."Biochemistry 29:3570-3578(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites."Biochemistry 30:7135-7141(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of the disulfide bonds of human complement C1s."Biochemistry 30:2827-2833(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling."Biochemistry 34:7311-7321(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2."J. Biol. Chem. 276:40880-40887(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases."J. Immunol. 166:7612-7616(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle."EMBO J. 19:1755-1765(2000) [PubMed] [Europe PMC] [Abstract]
  19. "X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement."J. Biol. Chem. 278:32157-32164(2003) [PubMed] [Europe PMC] [Abstract]