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Gonadotropin Releasing Hormone Receptor (GnRHR)

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GnRH-R; LRHR; Luteinizing Hormone Releasing Hormone Receptor

Gonadotropin Releasing Hormone Receptor (GnRHR)
CCC B672
HGNC 4421
MGI 95790
PubMed 15240592
RGD 70513
UniProt P30968
Wiki GNRHR

  • The gonadotropin-releasing hormone receptor (GNRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate.

  • This receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Evidence exists showing the presence of LHRH and its receptor in extrapituitary tissues as well as a role in progression of some cancers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gonadotropin Releasing Hormone Receptor (GnRHR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gonadotropin Releasing Hormone Receptor (GnRHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gonadotropin Releasing Hormone Receptor (GnRHR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gonadotropin Releasing Hormone Receptor (GnRHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gonadotropin Releasing Hormone Receptor (GnRHR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gonadotropin Releasing Hormone Receptor (GnRHR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gonadotropin Releasing Hormone Receptor (GnRHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gonadotropin Releasing Hormone Receptor (GnRHR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gonadotropin Releasing Hormone Receptor (GnRHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gonadotropin Releasing Hormone Receptor (GnRHR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB672Ra01 Recombinant Gonadotropin Releasing Hormone Receptor (GnRHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB672Ra01 Polyclonal Antibody to Gonadotropin Releasing Hormone Receptor (GnRHR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Gonadotropin Releasing Hormone Receptor (GnRHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gonadotropin Releasing Hormone Receptor (GnRHR) ELISA Kit Customized Service Offer
  1. "Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor."Biochem. Biophys. Res. Commun. 189:289-295(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of the human GnRH receptor."Mol. Cell. Endocrinol. 91:R1-R6(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary."Mol. Cell. Endocrinol. 106:145-149(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular structure of the human gonadotropin-releasing hormone receptor gene."Eur. J. Endocrinol. 137:183-192(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor."Mol. Endocrinol. 11:1305-1318(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene."Eur. J. Endocrinol. 140:561-569(1999) [PubMed] [Europe PMC] [Abstract]
  8. "A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor."N. Engl. J. Med. 337:1597-1602(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism."Nat. Genet. 18:14-15(1998) [PubMed] [Europe PMC] [Abstract]
  10. "The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred."J. Clin. Endocrinol. Metab. 84:567-572(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration."J. Clin. Endocrinol. Metab. 84:990-996(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor."J. Clin. Endocrinol. Metab. 84:3811-3816(1999) [PubMed] [Europe PMC] [Abstract]
  13. "The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor."J. Clin. Endocrinol. Metab. 86:2470-2475(2001) [PubMed] [Europe PMC] [Abstract]
  14. "A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene."Clin. Endocrinol. (Oxf.) 54:493-498(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction."J. Clin. Endocrinol. Metab. 86:2680-2686(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site."J. Clin. Endocrinol. Metab. 87:2144-2149(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism."J. Clin. Endocrinol. Metab. 88:1873-1879(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
  19. "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]