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Major Basic Protein (MBP)

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PRG2; BMPG; Proteoglycan 2; Bone Marrow,Natural Killer Cell Activator; Eosinophil Granule Major Basic Protein; Proteoglycan 2,Bone Marrow; Pregnancy-associated major basic

Major Basic Protein (MBP)
CCC B650
HGNC 9362
MGI 103294
PubMed 7230899
RGD 69336
UniProt P13727
Wiki MBP

  • Major basic protein The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Hu01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
CPB650Hu21 OVA Conjugated Major Basic Protein (MBP) Immunogen; SDS-PAGE; WB.
RPB650Hu02 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Hu01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu21 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
PAB650Hu08 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu22 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
PAB650Hu02 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu23 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu24 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu25 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu27 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu29 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
Assay Kits SEB650Hu ELISA Kit for Major Basic Protein (MBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Mu01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB650Mu02 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Mu01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
PAB650Mu02 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
LAB650Mu71 Biotin-Linked Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC.
Assay Kits SEB650Mu ELISA Kit for Major Basic Protein (MBP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB650Mu CLIA Kit for Major Basic Protein (MBP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Ra01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Ra01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Ra21 Monoclonal Antibody to Major Basic Protein (MBP) WB
MAB650Ra22 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Ra23 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Major Basic Protein (MBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Basic Protein (MBP) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Po01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Po01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Major Basic Protein (MBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Basic Protein (MBP) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Basic Protein (MBP) Recombinant Protein Customized Service Offer
Antibodies PAB650Bo01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
LAB650Bo71 Biotin-Linked Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Major Basic Protein (MBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Basic Protein (MBP) ELISA Kit Customized Service Offer
  1. "Acidic precursor revealed in human eosinophil granule major basic protein cDNA."J. Exp. Med. 168:1493-1498(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein."Gene 86:285-289(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein."J. Exp. Med. 168:2295-2308(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins."Mol. Immunol. 29:537-546(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters."Biochem. J. 305:921-927(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Pro-major basic protein has three types of sugar chains at the pro-portion."Biochim. Biophys. Acta 1163:243-249(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein."J. Biol. Chem. 268:12243-12246(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."J. Biol. Chem. 270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein."J. Biol. Chem. 263:12559-12563(1988) [PubMed] [Europe PMC] [Abstract]
  13. "Antibiotic proteins of human polymorphonuclear leukocytes."Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]
  14. "Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase."J. Leukoc. Biol. 43:1-4(1988) [PubMed] [Europe PMC] [Abstract]
  15. "Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA."Biochemistry 33:1592-1598(1994) [PubMed] [Europe PMC] [Abstract]
  16. "Evidence of eosinophil granule major basic protein in human placenta."J. Exp. Med. 170:2051-2063(1989) [PubMed] [Europe PMC] [Abstract]
  17. "Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum."Biochem. Mol. Biol. Int. 33:329-336(1994) [PubMed] [Europe PMC] [Abstract]
  18. "Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein."FEBS Lett. 341:213-217(1994) [PubMed] [Europe PMC] [Abstract]
  19. "Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta."Lab. Invest. 71:560-566(1994) [PubMed] [Europe PMC] [Abstract]
  20. "Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues."Biol. Reprod. 61:1083-1089(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor."J. Biol. Chem. 275:31128-31133(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites."J. Biol. Chem. 278:2106-2117(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase." J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity."J. Biol. Chem. 276:26197-26203(2001) [PubMed] [Europe PMC] [Abstract]
  25. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]