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Ankyrin 1, Erythrocytic (ANK1)

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ANK; SPH1; SPH2; Ankyrin-R

Ankyrin 1, Erythrocytic (ANK1)
CCC B633
HGNC 492
MGI 88024
PubMed 8640229
RGD 1309620
UniProt P16157
Wiki ANK1_(gene
Ankyrin 1was first discovered in erythrocytes, but since has also been found in brain and muscles.The ANK1 protein belongs to the ankyrin family that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB633Hu01 Recombinant Ankyrin 1, Erythrocytic (ANK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB633Hu01 Polyclonal Antibody to Ankyrin 1, Erythrocytic (ANK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ankyrin 1, Erythrocytic (ANK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin 1, Erythrocytic (ANK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin 1, Erythrocytic (ANK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin 1, Erythrocytic (ANK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin 1, Erythrocytic (ANK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin 1, Erythrocytic (ANK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin 1, Erythrocytic (ANK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin 1, Erythrocytic (ANK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin 1, Erythrocytic (ANK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin 1, Erythrocytic (ANK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin 1, Erythrocytic (ANK1) ELISA Kit Customized Service Offer
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  2. "cDNA sequence for human erythrocyte ankyrin."Proc. Natl. Acad. Sci. U.S.A. 87:1730-1734(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing."J. Biol. Chem. 272:19220-19228(1997) [PubMed] [Europe PMC] [Abstract]
  4. "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene."J. Biol. Chem. 273:1339-1348(1998) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
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  8. "Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor."J. Biol. Chem. 286:7648-7660(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger."J. Biol. Chem. 270:22050-22057(1995) [PubMed] [Europe PMC] [Abstract]
  10. "The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin."J. Biol. Chem. 278:3985-3991(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles."J. Cell Biol. 160:245-253(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
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  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of a 12 ANK repeat stack from human ankyrinR."EMBO J. 21:6387-6396(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the DEATH domain of ankyrin-1."Submitted (APR-2008) to the PDB data bank
  18. "Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin."J. Mol. Biol. 417:336-350(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis."Nat. Genet. 13:214-218(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Low frequency of ankyrin mutations in hereditary spherocytosis: identification of three novel mutations."Hum. Mutat. 16:529-529(2000) [PubMed] [Europe PMC] [Abstract]
  21. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]