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Surfactant Protein C (SP-C)

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SFTPC; PSP-C; SFTP2; SPC; SP5; Surfactant Associated Protein C; Pulmonary Surfactant Protein C; Pulmonary surfactant-associated proteolipid SPL(Val)

Surfactant Protein C (SP-C)
CCC B623
HGNC 10802
MGI 109517
PubMed 1591008
RGD 3666
UniProt P11686
Wiki SPC

  • SP-C is a fragment of a much larger precursor protein of 21 kD. The precursor contains an exceedingly hydrophobic region of 34 amino acids that comprises most of the mature SP C, and a unique poly-valine domain.Pulmonary surfactant-associated protein C is a membrane protein which manufactures surfactant.Humans and animals born lacking SP-C tend to develop progressive interstitial pneumonitis.The SFTPC gene encodes pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. It is produced exclusively by type II alveolar epithelial cells in the lung. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB623Hu01 Recombinant Surfactant Protein C (SP-C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB623Hu01 Polyclonal Antibody to Surfactant Protein C (SP-C) WB; IHC; ICC; IP.
MAB623Hu22 Monoclonal Antibody to Surfactant Protein C (SP-C) WB
Assay Kits SEB623Hu ELISA Kit for Surfactant Protein C (SP-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB623Mu01 Recombinant Surfactant Protein C (SP-C) Positive Control; Immunogen; SDS-PAGE; WB.
RPB623Mu02 Recombinant Surfactant Protein C (SP-C) Positive Control; Immunogen; SDS-PAGE; WB.
APB623Mu01 Active Surfactant Protein C (SP-C) Cell culture; Activity Assays.
Antibodies PAB623Mu01 Polyclonal Antibody to Surfactant Protein C (SP-C) WB; IHC; ICC; IP.
PAB623Mu02 Polyclonal Antibody to Surfactant Protein C (SP-C) WB; IHC; ICC; IP.
Assay Kits SEB623Mu ELISA Kit for Surfactant Protein C (SP-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB623Ra01 Recombinant Surfactant Protein C (SP-C) Positive Control; Immunogen; SDS-PAGE; WB.
RPB623Ra02 Recombinant Surfactant Protein C (SP-C) Positive Control; Immunogen; SDS-PAGE; WB.
APB623Ra01 Active Surfactant Protein C (SP-C) Cell culture; Activity Assays.
Antibodies PAB623Ra01 Polyclonal Antibody to Surfactant Protein C (SP-C) WB; IHC; ICC; IP.
MAB623Ra21 Monoclonal Antibody to Surfactant Protein C (SP-C) WB; IHC; ICC; IP.
PAB623Ra02 Polyclonal Antibody to Surfactant Protein C (SP-C) WB; IHC; ICC; IP.
Assay Kits SEB623Ra ELISA Kit for Surfactant Protein C (SP-C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Surfactant Protein C (SP-C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Surfactant Protein C (SP-C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Surfactant Protein C (SP-C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Surfactant Protein C (SP-C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Surfactant Protein C (SP-C) ELISA Kit Customized Service Offer
  1. "Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences."Proc. Natl. Acad. Sci. U.S.A. 84:7915-7919(1987) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal)."J. Biol. Chem. 263:9-12(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Two SP-C genes encoding human pulmonary surfactant proteolipid."J. Biol. Chem. 263:10326-10331(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species."Exp. Lung Res. 20:57-72(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms."FEBS Lett. 232:61-64(1988) [PubMed] [Europe PMC] [Abstract]
  9. "Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups."Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990) [PubMed] [Europe PMC] [Abstract]
  10. "High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C."Proc. Natl. Acad. Sci. U.S.A. 109:2325-2329(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred."Am. J. Respir. Crit. Care Med. 165:1322-1328(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease."Am. J. Med. Genet. A 126:18-26(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Surfactant protein C gene variation in the Finnish population -association with perinatal respiratory disease."Eur. J. Hum. Genet. 12:312-320(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene."Eur. Respir. J. 24:30-39(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Variable phenotype associated with SP-C gene mutations: fatal case with the I73T mutation."Eur. Respir. J. 24:1072-1073(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Hydroxychloroquine and surfactant protein C deficiency."N. Engl. J. Med. 352:207-208(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene."Pediatr. Res. 57:89-98(2005) [PubMed] [Europe PMC] [Abstract]