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C4 Binding Protein Alpha (C4BPa)

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C4BP-a; PRP; C4BP; Complement Component 4 Binding Protein,Alpha; Proline-rich protein

C4 Binding Protein Alpha (C4BPa)
CCC B620
HGNC 1325
MGI 88229
PubMed 2237642
RGD 2235
UniProt P04003
Wiki 12232502
C4b-binding protein is involved in regulation of the complement system. It is a multimeric protein comprising 7 identical alpha chains, encoded by C4BPA, and a single beta chain, encoded by C4BPB. The alpha and beta chains have molecular masses of 70 and 45 kD, respectively. Both subunits belong to a superfamily of proteins composed predominantly of tandemly arranged short consensus repeats (SCR) of approximately 60 amino acids in length (Aso et al., 1991).
Brodeur et al. (2003) identified a 23-kD protein that bound CD40 as C4BP-alpha. Flow cytometric analysis demonstrated binding of C4BP to human B-cell lines expressing CD40, but not to cells from CD40-deficient patients.Aso et al. (1991) found that the C4BPA gene comprises 12 exons and spans about 40 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB620Hu01 Recombinant C4 Binding Protein Alpha (C4BPa) Positive Control; Immunogen; SDS-PAGE; WB.
APB620Hu01 Active C4 Binding Protein Alpha (C4BPa) Cell culture; Activity Assays.
Antibodies PAB620Hu01 Polyclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC; IP.
MAB620Hu22 Monoclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC; IP.
LAB620Hu71 Biotin-Linked Polyclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC.
LAB620Hu81 FITC-Linked Polyclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC; IF.
Assay Kits SEB620Hu ELISA Kit for C4 Binding Protein Alpha (C4BPa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB620Mu01 Recombinant C4 Binding Protein Alpha (C4BPa) Positive Control; Immunogen; SDS-PAGE; WB.
RPB620Mu02 Recombinant C4 Binding Protein Alpha (C4BPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB620Mu01 Polyclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC; IP.
PAB620Mu02 Polyclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for C4 Binding Protein Alpha (C4BPa) CLIA Kit Customized Service Offer
n/a ELISA Kit for C4 Binding Protein Alpha (C4BPa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB620Ra01 Recombinant C4 Binding Protein Alpha (C4BPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB620Ra01 Polyclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC; IP.
MAB620Ra21 Monoclonal Antibody to C4 Binding Protein Alpha (C4BPa) WB; IHC; ICC; IP.
Assay Kits SEB620Ra ELISA Kit for C4 Binding Protein Alpha (C4BPa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein."Biochem. Biophys. Res. Commun. 165:138-144(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the alpha chain of the human C4b-binding protein gene."Biochem. Biophys. Res. Commun. 174:222-227(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence."FEBS Lett. 232:328-332(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Studies on the structure of the human C4b-binding protein gene."FEBS Lett. 204:77-81(1986) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system."Biochem. J. 230:133-141(1985) [PubMed] [Europe PMC] [Abstract]
  8. "Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment."Mol. Immunol. 22:427-435(1985) [PubMed] [Europe PMC] [Abstract]
  9. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b."Proc. Natl. Acad. Sci. U.S.A. 80:3461-3465(1983) [PubMed] [Europe PMC] [Abstract]
  14. "Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor."J. Biol. Chem. 281:3690-3697(2006) [PubMed] [Europe PMC] [Abstract]