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Thymosin Beta 4 (TMSB4X)

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Tb4; FX; PTMB4; TB4X; TMSB4; Thymosin,Beta 4,X-Linked; TB-500; Seraspenide; Hematopoietic system regulatory peptide

Thymosin Beta 4 (TMSB4X)
CCC B609
HGNC 11881
MGI 99510
PubMed 20536454
RGD 621622
UniProt P62328
Wiki TB4

The predominant form of thymosin, thymosin beta4, is a member of a highly conserved family of actin monomer-sequestering proteins. Beta-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.

Thymosin beta4 sequesters actin, holding it in a form that is unable to polymerize. Due to its profusion in the cytosol and its ability to bind ATP G-actin but not F-actin, thymosin beta4 is regarded as the principal actin-sequestering protein. Thymosin beta4 binds ATP G- monomeric actin in a 11 complex where G-actin cannot polymerize.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB609Hu01 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
CPB609Hu21 OVA Conjugated Thymosin Beta 4 (TMSB4X) Immunogen; SDS-PAGE; WB.
CPB609Hu11 BSA Conjugated Thymosin Beta 4 (TMSB4X) Immunogen; SDS-PAGE; WB.
APB609Hu01 Active Thymosin Beta 4 (TMSB4X) Cell culture; Activity Assays.
EPB609Hu61 Eukaryotic Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
RPB609Hu02 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
RPB609Hu03 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
APB609Hu61 Active Thymosin Beta 4 (TMSB4X) Cell culture; Activity Assays.
APB609Hu03 Active Thymosin Beta 4 (TMSB4X) Cell culture; Activity Assays.
Antibodies PAB609Hu01 Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
LAB609Hu71 Biotin-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC.
MAB609Hu21 Monoclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
PAB609Hu08 Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
PAB609Hu03 Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
Assay Kits CEB609Hu ELISA Kit for Thymosin Beta 4 (TMSB4X) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB609Mu01 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB609Mu01 Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
LAB609Mu71 Biotin-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC.
LAB609Mu81 FITC-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Thymosin Beta 4 (TMSB4X) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymosin Beta 4 (TMSB4X) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB609Ra01 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
RPB609Ra02 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB609Ra01 Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
LAB609Ra71 Biotin-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Thymosin Beta 4 (TMSB4X) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymosin Beta 4 (TMSB4X) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB609Bo01 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
RPB609Bo02 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB609Bo01 Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
LAB609Bo71 Biotin-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC.
LAB609Bo81 FITC-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Thymosin Beta 4 (TMSB4X) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymosin Beta 4 (TMSB4X) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB609Eq01 Recombinant Thymosin Beta 4 (TMSB4X) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB609Eq01 Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IP.
LAB609Eq71 Biotin-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC.
LAB609Eq81 FITC-Linked Polyclonal Antibody to Thymosin Beta 4 (TMSB4X) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Thymosin Beta 4 (TMSB4X) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thymosin Beta 4 (TMSB4X) ELISA Kit Customized Service Offer
  1. "Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes."J. Immunol. 139:3840-3848(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and structural characterization of the functional human thymosin beta4 gene."Mol. Cell. Biochem. 272:97-105(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable."J. Biol. Chem. 266:4029-4032(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells."Cell 38:745-755(1984) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity."Eur. J. Biochem. 267:3530-3538(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Structural states and dynamics of the D-loop in actin."Biophys. J. 103:930-939(2012) [PubMed] [Europe PMC] [Abstract]