≡

Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3)

[Edit]

1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta-3

Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3)
CCC B605
HGNC 9056
MGI 104778
PubMed 7789993
RGD 61993
UniProt Q01970
Wiki PLCB3

Phosphatidylinositol-specific phospholipase C (PIPLC), an enzyme that can specifically release phosphatidylinositol-linked proteins from host cells, is one of the extracellular enzymes produced by Staphylococcus aureus.

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB605Hu01 Recombinant Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB605Hu01 Polyclonal Antibody to Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB605Mu01 Recombinant Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB605Mu01 Polyclonal Antibody to Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Beta 3, Phosphoinositide Specific (PLCb3) ELISA Kit Customized Service Offer
  1. "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene."Biochem. Biophys. Res. Commun. 212:190-195(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)."Genomics 26:467-472(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily."Eur. J. Biochem. 210:521-529(1992) [PubMed] [Europe PMC] [Abstract]
  6. "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation."Mol. Cell. Biol. 24:5069-5079(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]