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C-Type Lectin Domain Family 4, Member K (CLEC4K)

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CD207; Langerin

C-Type Lectin Domain Family 4, Member K (CLEC4K)
CCC B602
HGNC 17935
MGI 2180021
PubMed 11978773
RGD 1565913
UniProt Q9UJ71
Wiki CD207

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene. Langerin is a type II transmembrane cell surface receptor produced by Langerhans cells.Langerin is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa.

It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB602Hu01 Recombinant C-Type Lectin Domain Family 4, Member K (CLEC4K) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB602Hu01 Polyclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K) WB; IHC; ICC; IP.
MAB602Hu22 Monoclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K) WB; IHC; ICC; IP.
MAB602Hu21 Monoclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K) WB; IHC; ICC; IP.
Assay Kits SEB602Hu ELISA Kit for C-Type Lectin Domain Family 4, Member K (CLEC4K) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 4, Member K (CLEC4K) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 4, Member K (CLEC4K) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 4, Member K (CLEC4K) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 4, Member K (CLEC4K) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 4, Member K (CLEC4K) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 4, Member K (CLEC4K) ELISA Kit Customized Service Offer
  1. "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules."Immunity 12:71-81(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells."Glycobiology 13:401-410(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Langerin/CD207 sheds light on formation of Birbeck granules and their possible function in Langerhans cells."Immunol. Res. 28:93-107(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells."Nat. Med. 13:367-371(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Dual specificity of langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain."J. Biol. Chem. 285:6390-6400(2010) [PubMed] [Europe PMC] [Abstract]
  9. "C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi."Mol. Immunol. 47:1216-1225(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Structural studies of langerin and Birbeck granule: a macromolecular organization model."Biochemistry 48:2684-2698(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene."J. Invest. Dermatol. 124:714-717(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Polymorphisms in human langerin affect stability and sugar binding activity."J. Biol. Chem. 281:15450-15456(2006) [PubMed] [Europe PMC] [Abstract]