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Phospholipase C Beta 1 (PLCB1)

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PLCb1; PLC-B1; PI-PLC; PLC-154; PLC-I; 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta-1; Phospholipase C Beta 1, Phosphoinositide Specific; Phospholipase C-I

Phospholipase C Beta 1 (PLCB1)
CCC B596
HGNC 15917
MGI 97613
PubMed 22507702
RGD 3344
UniProt Q9NQ66
Wiki PLCB1

Phospholipase C-beta (PLCB) catalyzes the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate (IP2), a key step in the intracellular transduction of many extracellular signals. PLCB1 is one of several mammalian PLCB isoforms which differ in their function and expression patterns in vivo.

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB596Hu01 Recombinant Phospholipase C Beta 1 (PLCB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB596Hu01 Polyclonal Antibody to Phospholipase C Beta 1 (PLCB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phospholipase C Beta 1 (PLCB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Beta 1 (PLCB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Beta 1 (PLCB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Beta 1 (PLCB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Beta 1 (PLCB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Beta 1 (PLCB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Beta 1 (PLCB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Beta 1 (PLCB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Beta 1 (PLCB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Beta 1 (PLCB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Beta 1 (PLCB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Beta 1 (PLCB1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1)."Biochim. Biophys. Acta 1517:63-72(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta 1."Biochim. Biophys. Acta 1484:175-182(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus."Exp. Cell Res. 287:143-154(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy."Brain 133:2964-2970(2010) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]