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Palladin (PALLD)

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Cytoskeletal Associated Protein; Sarcoma antigen NY-SAR-77

Palladin (PALLD)
CCC B590
HGNC 17068
MGI 1919583
PubMed 23524582
RGD 1359390
UniProt Q8WX93
Wiki Palladin

Palladin is a cytoplasmic member of the myotilin/palladin family of proteins. As a cytoskeletal protein required for organization of normal actin cytoskeleton, it plays a role in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. Palladin is widely expressed and interacts with actin-associated proteins. Also, it may function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. There are many different isoforms of Paladin, and these isoforms may have functional differences. For example, involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation, involved in targeting ACTN to specific subcellular foci.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB590Hu01 Recombinant Palladin (PALLD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB590Hu01 Polyclonal Antibody to Palladin (PALLD) WB,IHC
MAB590Hu22 Monoclonal Antibody to Palladin (PALLD) WB; IHC; ICC; IP.
Assay Kits SEB590Hu ELISA Kit for Palladin (PALLD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Palladin (PALLD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Palladin (PALLD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Palladin (PALLD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Palladin (PALLD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Palladin (PALLD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Palladin (PALLD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Palladin (PALLD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Palladin (PALLD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Palladin (PALLD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Palladin (PALLD) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Immunomic analysis of human sarcoma."Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of human palladin, a microfilament-associated protein."Mol. Biol. Cell 12:3060-3073(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular analysis of the interaction between palladin and alpha-actinin."FEBS Lett. 566:30-34(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton."Exp. Cell Res. 310:88-98(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The proline-rich protein palladin is a binding partner for profilin."FEBS J. 273:26-33(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Isoform-specific regulation of the actin-organizing protein Palladin during TGF-beta1-induced myofibroblast differentiation."J. Invest. Dermatol. 126:2387-2396(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration."Circ. Res. 100:817-825(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling."Exp. Cell Res. 313:2575-2585(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism."PLoS Med. 3:2216-2228(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Identification of four gene variants associated with myocardial infarction."Am. J. Hum. Genet. 77:596-605(2005) [PubMed] [Europe PMC] [Abstract]
  19. "The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer."Hum. Genet. 121:635-637(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Palladin mutation causes familial pancreatic cancer: absence in European families."PLoS Med. 4:774-775(2007) [PubMed] [Europe PMC] [Abstract]
  21. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  23. "The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration."Mol. Cell 38:333-344(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  28. "Expression, crystallization and preliminary X-ray studies of the immunoglobulin-like domain 3 of human palladin."Acta Crystallogr. F 62:556-558(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the first and second Ig domains of human palladin."Submitted (APR-2007) to the PDB data bank