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Integrin Linked Kinase (ILK)

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ILK1; P59; 59 kDa serine/threonine-protein kinase

Integrin Linked Kinase (ILK)
CCC B587
HGNC 6040
MGI 1195267
PubMed 12884912
RGD 620063
UniProt Q13418
Wiki ILK

Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin beta 1 as the bait protein. Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, signal transduction. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB587Hu01 Recombinant Integrin Linked Kinase (ILK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB587Hu01 Polyclonal Antibody to Integrin Linked Kinase (ILK) WB; IHC; ICC; IP.
Assay Kits SEB587Hu ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Linked Kinase (ILK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Linked Kinase (ILK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Linked Kinase (ILK) Polyclonal Antibody Customized Service Offer
Assay Kits SEB587Mu ELISA Kit for Integrin Linked Kinase (ILK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Linked Kinase (ILK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Linked Kinase (ILK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Linked Kinase (ILK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Linked Kinase (ILK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Linked Kinase (ILK) ELISA Kit Customized Service Offer
  1. "Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase."Nature 379:91-96(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation."Oncogene 19:3069-3077(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase."Proc. Natl. Acad. Sci. U.S.A. 95:11211-11216(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Cell-substrate interactions and signaling through ILK."Curr. Opin. Cell Biol. 12:250-256(2000) [PubMed] [Europe PMC] [Abstract]
  9. "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction."J. Cell Biol. 153:1251-1264(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration."J. Biol. Chem. 277:38328-38338(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival."J. Biol. Chem. 279:41695-41705(2004) [PubMed] [Europe PMC] [Abstract]
  12. "EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility."J. Cell Sci. 122:243-255(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "The structural basis of integrin-linked kinase-PINCH interactions."Proc. Natl. Acad. Sci. U.S.A. 105:20677-20682(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase."J. Biol. Chem. 284:5836-5844(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The pseudoactive site of ILK is essential for its binding to alpha-parvin and localization to focal adhesions."Mol. Cell 36:819-830(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ."J. Mol. Biol. 397:457-466(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells." Circulation 116:515-525(2007) [PubMed] [Europe PMC] [Abstract]