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Myeloid Progenitor Inhibitory Factor 1 (MPIF1)

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CCL23; SCYA23; Ckb-8; MIP-3; CKb8; Chemokine(C-C-Motif)ligand 23; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 23; Macrophage inflammatory protein 3

Myeloid Progenitor Inhibitory Factor 1 (MPIF1)
CCC B574
HGNC 10622
PubMed 17130244
UniProt P55773
Wiki CCL23

Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). CCL23 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta.

It is also expressed in some cell lines of myeloid origin. CCL23 is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells.The gene for CCL23 is located on human chromosome 17 in a locus containing several other CC chemokines. CCL23 is a ligand for the chemokine receptor CCR1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB574Hu01 Recombinant Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Positive Control; Immunogen; SDS-PAGE; WB.
APB574Hu01 Active Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Cell culture; Activity Assays.
EPB574Hu61 Eukaryotic Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Positive Control; Immunogen; SDS-PAGE; WB.
APB574Hu61 Active Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Cell culture; Activity Assays.
Antibodies PAB574Hu01 Polyclonal Antibody to Myeloid Progenitor Inhibitory Factor 1 (MPIF1) WB; IHC; ICC; IP.
MAB574Hu22 Monoclonal Antibody to Myeloid Progenitor Inhibitory Factor 1 (MPIF1) WB; IHC; ICC; IP.
LAB574Hu71 Biotin-Linked Polyclonal Antibody to Myeloid Progenitor Inhibitory Factor 1 (MPIF1) WB; IHC; ICC.
PAB574Hu06 Polyclonal Antibody to Myeloid Progenitor Inhibitory Factor 1 (MPIF1) WB; IHC; ICC; IP.
Assay Kits SEB574Hu ELISA Kit for Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB574Hu CLIA Kit for Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid Progenitor Inhibitory Factor 1 (MPIF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid Progenitor Inhibitory Factor 1 (MPIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid Progenitor Inhibitory Factor 1 (MPIF1) ELISA Kit Customized Service Offer
  1. "Macrophage inflammatory protein-3 and -4."Patent number US5504003, 02-APR-1996
  2. "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors."J. Exp. Med. 185:1163-1172(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1."Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Proteolytic activation of alternative CCR1 ligands in inflammation."J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine."J. Biol. Chem. 276:4909-4916(2001) [PubMed] [Europe PMC] [Abstract]