Z-DNA Binding Protein 1 (ZBP1)

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DLM1; DAI; DNA-Dependent Activator Of IRFs; Tumor stroma and activated macrophage protein DLM-1

Z-DNA Binding Protein 1 (ZBP1)
  • Using fragments derived from these exons, EST database searching, and PCR analysis, they cloned human DLM1 cDNA. They also cloned a rat DLM1 cDNA. Human DLM1 encodes a deduced 429-amino acid protein with 47% and 46% sequence identity with the mouse and rat homologs, respectively. All 3 proteins contain 4 conserved regions, 2 of which are homologous to the Z-DNA binding domains Z-alpha and Z-beta of the RNA editing enzyme ADAR.

  • By RT-PCR of human tissues, Rothenburg et al. (2002) found prominent expression of DLM1 in the small intestine and lymphatic tissues, including lymph node, leukocytes and spleen; detectable expression in thymus, lung, liver, and pancreas; and no expression in brain and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB552Hu01 Recombinant Z-DNA Binding Protein 1 (ZBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB552Hu01 Polyclonal Antibody to Z-DNA Binding Protein 1 (ZBP1) WB; IHC; ICC; IP.
Assay Kits SEB552Hu ELISA Kit for Z-DNA Binding Protein 1 (ZBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Z-DNA Binding Protein 1 (ZBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Z-DNA Binding Protein 1 (ZBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Z-DNA Binding Protein 1 (ZBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Z-DNA Binding Protein 1 (ZBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Z-DNA Binding Protein 1 (ZBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Z-DNA Binding Protein 1 (ZBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Z-DNA Binding Protein 1 (ZBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Z-DNA Binding Protein 1 (ZBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Z-DNA Binding Protein 1 (ZBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Z-DNA Binding Protein 1 (ZBP1) ELISA Kit Customized Service Offer
  1. "Complex regulation of the human gene for the Z-DNA binding protein DLM-1."Nucleic Acids Res. 30:993-1000(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA."Proc. Natl. Acad. Sci. U.S.A. 105:20671-20676(2008) [PubMed] [Europe PMC] [Abstract]