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Poliovirus Receptor (PVR)

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CD155; HVED; Necl-5; Tage4; Nectin-Like Protein 5

Poliovirus Receptor (PVR)
CCC B550
HGNC 9705
MGI 107741
PubMed 10618374
RGD 3813
UniProt P15151
Wiki CD155

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses.

This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB550Hu01 Recombinant Poliovirus Receptor (PVR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB550Hu02 Recombinant Poliovirus Receptor (PVR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB550Hu01 Polyclonal Antibody to Poliovirus Receptor (PVR) WB; IHC; ICC; IP.
MAB550Hu22 Monoclonal Antibody to Poliovirus Receptor (PVR) WB; IHC; ICC; IP.
PAB550Hu02 Polyclonal Antibody to Poliovirus Receptor (PVR) WB; IHC; ICC; IP.
Assay Kits SEB550Hu ELISA Kit for Poliovirus Receptor (PVR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poliovirus Receptor (PVR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poliovirus Receptor (PVR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poliovirus Receptor (PVR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poliovirus Receptor (PVR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poliovirus Receptor (PVR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB550Ra01 Recombinant Poliovirus Receptor (PVR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB550Ra01 Polyclonal Antibody to Poliovirus Receptor (PVR) WB; IHC; ICC; IP.
LAB550Ra81 FITC-Linked Polyclonal Antibody to Poliovirus Receptor (PVR) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Poliovirus Receptor (PVR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poliovirus Receptor (PVR) ELISA Kit Customized Service Offer
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  8. "The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin."Virology 285:218-227(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis."J. Biol. Chem. 277:7897-7904(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog."J. Biol. Chem. 277:25697-25702(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains."J. Biol. Chem. 278:31251-31260(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts."Biochem. Biophys. Res. Commun. 319:1253-1264(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)."Int. Immunol. 16:533-538(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome."J. Virol. 78:7186-7198(2004) [PubMed] [Europe PMC] [Abstract]
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  18. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  19. "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141."Nat. Immunol. 6:181-188(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  22. "The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Interaction of the poliovirus receptor with poliovirus."Proc. Natl. Acad. Sci. U.S.A. 97:79-84(2000) [PubMed] [Europe PMC] [Abstract]
  25. "Complexes of poliovirus serotypes with their common cellular receptor, CD155."J. Virol. 77:4827-4835(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering."Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404(2012) [PubMed] [Europe PMC] [Abstract]