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Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1)

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Addressin

Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1)
CCC B521
HGNC 6765
MGI 103579
PubMed 11546645
RGD 3029
UniProt Q13477
Wiki Addressin
Addressin is an extracellular protein of the endothelium of venules. Addressins are the ligands to the homing receptors of lymphocytes.The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. The carry carbohydrates in order to be recognized by L-selectin.
The predicted amino acid sequence defines the mucosal addressin as a novel immunoglobulin family member with 2 N-terminal domains that display strong homology to previously described vascular adhesion receptors for leukocytes: ICAM1 and VCAM1. The membrane proximal domain is homologous to the third domain of another mucosa-associated member of the immunoglobulin family, namely, IgA1 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB521Hu01 Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB521Hu01 Polyclonal Antibody to Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) WB; IHC; ICC; IP.
MAB521Hu22 Monoclonal Antibody to Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) WB; IHC; ICC; IP.
Assay Kits SEB521Hu ELISA Kit for Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB521Mu01 Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB521Mu02 Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB521Mu01 Polyclonal Antibody to Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) WB; IHC; ICC; IP.
PAB521Mu02 Polyclonal Antibody to Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) WB; IHC; ICC; IP.
Assay Kits SEB521Mu ELISA Kit for Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) ELISA Kit Customized Service Offer
  1. "Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts."Immunol. Cell Biol. 74:490-496(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences."J. Immunol. 156:2851-2857(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene."Immunogenetics 46:111-119(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition."Structure 6:793-801(1998) [PubMed] [Europe PMC] [Abstract]
  7. "A reassessment of the MAdCAM-1 structure and its role in integrin recognition."Acta Crystallogr. D 58:233-241(2002) [PubMed] [Europe PMC] [Abstract]