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Interleukin 2 Receptor Gamma (IL2Rg)

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CD132; IL2R-g; IL2-RG; CD132; IMD4; p64; SCIDX; SCIDX1; Cytokine Receptor Common Gamma Chain; Severe Combined Immunodeficiency

Interleukin 2 Receptor Gamma (IL2Rg)
CCC B512
HGNC 6010
MGI 96551
PubMed 9058718
RGD 621466
UniProt P31785
Wiki IL2RG

IL2RG is located on the surface of immature blood-forming cells in bone marrow. It has one end outside the cell like an antenna and the other end inside to transmit signals to the cell's nucleus. The common gamma chain partners with other proteins to direct blood-forming cells to form lymphocytes (a type of white blood cell). The receptor also directs the growth and maturation of lymphocyte subtypes: T cells, B cells, and natural killer cells. These cells kill viruses, make antibodies, and help regulate the entire immune system.X-linked severe combined immunodeficiency is caused by mutations in the IL2RG gene. More than 200 different mutations in the IL2RG gene have been identified in people with X-linked severe combined immunodeficiency (SCID).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB512Hu01 Recombinant Interleukin 2 Receptor Gamma (IL2Rg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB512Hu01 Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) WB; IHC
LAB512Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) WB; IHC; ICC.
MAB512Hu21 Monoclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) WB; IHC; ICC; IP.
Assay Kits SEB512Hu ELISA Kit for Interleukin 2 Receptor Gamma (IL2Rg) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB512Mu01 Recombinant Interleukin 2 Receptor Gamma (IL2Rg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB512Mu01 Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 2 Receptor Gamma (IL2Rg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 2 Receptor Gamma (IL2Rg) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 2 Receptor Gamma (IL2Rg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 2 Receptor Gamma (IL2Rg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 2 Receptor Gamma (IL2Rg) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB512Po01 Recombinant Interleukin 2 Receptor Gamma (IL2Rg) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 2 Receptor Gamma (IL2Rg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 2 Receptor Gamma (IL2Rg) ELISA Kit Customized Service Offer
  1. "Cloning of the gamma chain of the human IL-2 receptor."Science 257:379-382(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human interleukin-2 receptor gamma chain gene."J. Biol. Chem. 268:13601-13608(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1."Hum. Mol. Genet. 2:1099-1104(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4."Science 262:1874-1877(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor."Science 262:1880-1883(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor."Science 262:1877-1880(1993) [PubMed] [Europe PMC] [Abstract]
  9. "The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface."J. Virol. 70:3599-3605(1996) [PubMed] [Europe PMC] [Abstract]
  10. "IL-2 receptor signaling through the Shb adapter protein in T and NK cells."Biochem. Biophys. Res. Commun. 296:929-936(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The interleukin-2 and interleukin-4 receptors studied by molecular modelling."Structure 2:839-851(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."Science 310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Interleukin-2 (IL-2) receptor gamma chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL-2 receptor binding."Eur. J. Immunol. 24:475-479(1994) [PubMed] [Europe PMC] [Abstract]
  16. "Detection of three nonsense mutations and one missense mutation in the interleukin-2 receptor gamma chain gene in SCIDX1 that differently affect the mRNA processing."Genomics 21:291-293(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency."J. Immunol. 153:1310-1317(1994) [PubMed] [Europe PMC] [Abstract]
  18. "Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells."Proc. Natl. Acad. Sci. U.S.A. 91:9466-9470(1994) [PubMed] [Europe PMC] [Abstract]
  19. "Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency."Am. J. Hum. Genet. 57:564-571(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis."Hum. Genet. 96:427-432(1995) [PubMed] [Europe PMC] [Abstract]
  21. "Female germ line mosaicism as the origin of a unique IL-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency."J. Clin. Invest. 95:895-899(1995) [PubMed] [Europe PMC] [Abstract]
  22. "Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency."J. Clin. Invest. 95:1169-1173(1995) [PubMed] [Europe PMC] [Abstract]
  23. "Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells."N. Engl. J. Med. 335:1563-1567(1996) [PubMed] [Europe PMC] [Abstract]
  24. "B-cell-negative severe combined immunodeficiency associated with a common gamma chain mutation."Hum. Genet. 99:677-680(1997) [PubMed] [Europe PMC] [Abstract]
  25. "Maternal mosaicism for a novel interleukin-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency in a Navajo kindred."J. Clin. Immunol. 17:29-33(1997) [PubMed] [Europe PMC] [Abstract]
  26. "An interleukin-2 receptor gamma chain mutation with normal thymus morphology."J. Clin. Invest. 100:3036-3043(1997) [PubMed] [Europe PMC] [Abstract]