Interleukin 3 Receptor Alpha (IL3Ra)
[Edit]CD123; IL3R-A; IL3RY; IL3RAY; IL3R; IL3RAY; IL3RY; hIL-3Ra
-91505.jpg)
interleukin-3 receptor is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5).
The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB505Mu01 | Recombinant Interleukin 3 Receptor Alpha (IL3Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB505Mu02 | Recombinant Interleukin 3 Receptor Alpha (IL3Ra) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB505Mu01 | Active Interleukin 3 Receptor Alpha (IL3Ra) | Cell culture; Activity Assays. | |
| APB505Mu02 | Active Interleukin 3 Receptor Alpha (IL3Ra) | Cell culture; Activity Assays. | |
| Antibodies | PAB505Mu01 | Polyclonal Antibody to Interleukin 3 Receptor Alpha (IL3Ra) | WB; IHC; ICC; IP. |
| PAB505Mu02 | Polyclonal Antibody to Interleukin 3 Receptor Alpha (IL3Ra) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Interleukin 3 Receptor Alpha (IL3Ra) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Interleukin 3 Receptor Alpha (IL3Ra) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Interleukin 3 Receptor Alpha (IL3Ra) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Interleukin 3 Receptor Alpha (IL3Ra) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Interleukin 3 Receptor Alpha (IL3Ra) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Interleukin 3 Receptor Alpha (IL3Ra) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Interleukin 3 Receptor Alpha (IL3Ra) | ELISA Kit Customized Service Offer |
- "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors."Cell 66:1165-1174(1991) [PubMed] [Europe PMC] [Abstract]
- "Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor."Biochem. Biophys. Res. Commun. 208:360-367(1995) [PubMed] [Europe PMC] [Abstract]
- "A new isoform of IL-3 receptor alpha with novel differentiation activity and high affinity binding mode."J. Biol. Chem. 284:5763-5773(2009) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]