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Endoplasmic Reticulum Resident Protein 57 (ERp57)

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P58; ERp61; PDIA3; ERp60; GRP57; PI-PLC; GRP58; Glucose Regulated Protein,58kDa; Protein Disulfide Isomerase-Associated 3; Endoplasmic reticulum resident protein 57

Endoplasmic Reticulum Resident Protein 57 (ERp57)
CCC B497
HGNC 4606
MGI 95834
PubMed 20843786
RGD 68430
UniProt P30101
Wiki PDIA3

The PDIA3 protein has protein disulfide isomerase activity. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex (TAP1), which is essential for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface.

The cDNA encoding human GRP58 was cloned independently by Bourdi et al. (1995), Koivunen et al. (1996), and Hirano et al. (1995). All reported that the gene encodes a 505-amino acid polypeptide with significant homology to human protein disulfide isomerase (PDI). Bourdi et al. (1995) noted that the sequence includes a putative nuclear localization motif and an endoplasmic reticulum (ER)-retention/retrieval motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB497Hu01 Recombinant Endoplasmic Reticulum Resident Protein 57 (ERp57) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB497Hu01 Polyclonal Antibody to Endoplasmic Reticulum Resident Protein 57 (ERp57) WB; IHC; ICC; IP.
MAB497Hu22 Monoclonal Antibody to Endoplasmic Reticulum Resident Protein 57 (ERp57) WB; IHC; ICC; IP.
Assay Kits SEB497Hu ELISA Kit for Endoplasmic Reticulum Resident Protein 57 (ERp57) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endoplasmic Reticulum Resident Protein 57 (ERp57) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Resident Protein 57 (ERp57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Resident Protein 57 (ERp57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Resident Protein 57 (ERp57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Resident Protein 57 (ERp57) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endoplasmic Reticulum Resident Protein 57 (ERp57) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Resident Protein 57 (ERp57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Resident Protein 57 (ERp57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Resident Protein 57 (ERp57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Resident Protein 57 (ERp57) ELISA Kit Customized Service Offer
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  12. , Submitted (DEC-2008) to UniProtKB
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  16. "ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57."J. Biol. Chem. 281:33727-33738(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  22. "SERPINA2 is a novel gene with a divergent function from SERPINA1."PLoS ONE 8:E66889-E66889(2013) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "NMR assignment of the N-terminal domain a of the glycoprotein chaperone ERp57."J. Biomol. NMR 33:136-136(2005) [PubMed] [Europe PMC] [Abstract]
  25. "The solution structure of the second thioredoxin domain of human protein disulfide-isomerase A3."Submitted (OCT-2006) to the PDB data bank
  26. "Crystal structure of the bb' domains of the protein disulfide isomerase ERp57."Structure 14:1331-1339(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer."Immunity 30:21-32(2009) [PubMed] [Europe PMC] [Abstract]