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Lumican (LUM)

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LDC; SLRR2D; KSPG lumican; Keratan sulfate proteoglycan lumican

Lumican (LUM)
CCC B496
HGNC 6724
MGI 109347
PubMed 18949819
RGD 620984
UniProt P51884
Wiki Lumican

Lumican is a member of the small leucine-rich proteoglycan family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. The protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings.Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. Lumican belongs to the family of small leucine-rich repeat proteoglycans. Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB496Hu01 Recombinant Lumican (LUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB496Hu01 Polyclonal Antibody to Lumican (LUM) WB; IHC; ICC; IP.
MAB496Hu22 Monoclonal Antibody to Lumican (LUM) WB; IHC
LAB496Hu71 Biotin-Linked Polyclonal Antibody to Lumican (LUM) WB; IHC; ICC.
LAB496Hu81 FITC-Linked Polyclonal Antibody to Lumican (LUM) WB; IHC; ICC; IF.
MAB496Hu21 Monoclonal Antibody to Lumican (LUM) WB; IHC
MAB496Hu23 Monoclonal Antibody to Lumican (LUM) WB; IHC; ICC; IP.
MAB496Hu24 Monoclonal Antibody to Lumican (LUM) WB; IHC; ICC; IP.
MAB496Hu25 Monoclonal Antibody to Lumican (LUM) WB; IHC; ICC; IP.
Assay Kits SEB496Hu ELISA Kit for Lumican (LUM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB496Mu01 Recombinant Lumican (LUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB496Mu01 Polyclonal Antibody to Lumican (LUM) WB; IHC; ICC; IP.
LAB496Mu71 Biotin-Linked Polyclonal Antibody to Lumican (LUM) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Lumican (LUM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lumican (LUM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lumican (LUM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lumican (LUM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lumican (LUM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lumican (LUM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lumican (LUM) ELISA Kit Customized Service Offer
  1. "The human lumican gene. Organization, chromosomal location, and expression in articular cartilage."J. Biol. Chem. 270:21942-21949(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22."Genomics 27:481-488(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry."J. Biol. Chem. 279:26-33(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]