≡

Peptidylprolyl Isomerase E (PPIE)

[Edit]

PPI-E; CYP-33; PPIase E; Peptidyl Prolyl Cis/Trans Isomerase E; Cyclophilin E; Cyclophilin-33; Rotamase E

Peptidylprolyl Isomerase E (PPIE)
CCC B493
HGNC 9258
MGI 1917118
PubMed 9747881
RGD 1311411
UniProt Q9UNP9
Wiki PPIE_(gene

Peptidyl-prolyl cis-trans isomerase E is  a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities and also exhibit RNA-binding activity. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.

The PPIase activity of CYP33 is inhibited by CsA with kinetics similar to other CYPs. Northern blotting of T-cell mRNA revealed expression of a low abundance 1.6-kb CYP33 transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB493Hu01 Recombinant Peptidylprolyl Isomerase E (PPIE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB493Hu01 Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Peptidylprolyl Isomerase E (PPIE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylprolyl Isomerase E (PPIE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB493Mu01 Recombinant Peptidylprolyl Isomerase E (PPIE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB493Mu01 Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Peptidylprolyl Isomerase E (PPIE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylprolyl Isomerase E (PPIE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidylprolyl Isomerase E (PPIE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidylprolyl Isomerase E (PPIE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylprolyl Isomerase E (PPIE) ELISA Kit Customized Service Offer
  1. "Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines."Oncogene 17:1019-1026(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A nuclear RNA-binding cyclophilin in human T cells."FEBS Lett. 398:201-205(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair."J. Biol. Chem. 283:940-950(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the RNA recognition motif in peptidyl-prolyl cis-trans isomerase E."Submitted (NOV-2005) to the PDB data bank