Calreticulin (CALR)
[Edit]CRT; RO; SSA; CC1qR; ERp60; HACBP; grp60; CRTC; CRP55; Calregulin; Sicca Syndrome Antigen A; Autoantigen Ro; Endoplasmic reticulum resident protein 60
Calreticulin is a protein that binds Ca2 ions (a second messenger molecule in signal transduction), rendering it inactive. The Ca2 is bound with low affinity, but high capacity, and can be released on a signal. Calreticulin is located in storage compartments associated with the endoplasmic reticulum.
Calreticulin is also known as calregulin, CRP55, CaBP3 and calsequestrin-like protein. The term "Mobilferrin" is considered to be the same as calreticulin by some sources.Calreticulin binds to misfolded proteins and prevents them from being exported from the Endoplasmic reticulum to the Golgi apparatus.A similar quality control chaperone, calnexin, performs the same service for soluble proteins as does calreticulin.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB486Hu01 | Recombinant Calreticulin (CALR) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPB486Hu02 | Recombinant Calreticulin (CALR) | Positive Control; Immunogen; SDS-PAGE; WB. | |
CPB486Hu21 | OVA Conjugated Calreticulin (CALR) | Immunogen; SDS-PAGE; WB. | |
APB486Hu61 | Active Calreticulin (CALR) | Cell culture; Activity Assays. | |
EPB486Hu61 | Eukaryotic Calreticulin (CALR) | Positive Control; Immunogen; SDS-PAGE; WB. | |
RPB486Hu03 | Recombinant Calreticulin (CALR) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAB486Hu01 | Polyclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP; FCM |
MAB486Hu22 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
PAB486Hu02 | Polyclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP; FCM | |
LAB486Hu71 | Biotin-Linked Polyclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC. | |
PAB486Hu08 | Polyclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
Assay Kits | SEB486Hu | ELISA Kit for Calreticulin (CALR) | Enzyme-linked immunosorbent assay for Antigen Detection. |
CEB486Hu | ELISA Kit for Calreticulin (CALR) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB486Mu01 | Recombinant Calreticulin (CALR) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPB486Mu02 | Recombinant Calreticulin (CALR) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAB486Mu01 | Polyclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. |
PAB486Mu02 | Polyclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
Assay Kits | SEB486Mu | ELISA Kit for Calreticulin (CALR) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB486Ra01 | Recombinant Calreticulin (CALR) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB486Ra01 | Polyclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. |
MAB486Ra21 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
MAB486Ra22 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
MAB486Ra29 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
MAB486Ra24 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
MAB486Ra25 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
MAB486Ra27 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
MAB486Ra23 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
MAB486Ra28 | Monoclonal Antibody to Calreticulin (CALR) | WB; IHC; ICC; IP. | |
Assay Kits | SEB486Ra | ELISA Kit for Calreticulin (CALR) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCB486Ra | CLIA Kit for Calreticulin (CALR) | Chemiluminescent immunoassay for Antigen Detection. |
- "Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen."J. Clin. Invest. 85:1379-1391(1990) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the autoantigen calreticulin."J. Immunol. 147:3031-3039(1991) [PubMed] [Europe PMC] [Abstract]
- "The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters."J. Biol. Chem. 267:2557-2562(1992) [PubMed] [Europe PMC] [Abstract]
- "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Human placental calreticulin: purification, characterization and association with other proteins."Acta Chem. Scand. 48:905-911(1994) [PubMed] [Europe PMC] [Abstract]
- "Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide."J. Clin. Invest. 82:96-101(1988) [PubMed] [Europe PMC] [Abstract]
- "In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits."Biochemistry 30:9859-9866(1991) [PubMed] [Europe PMC] [Abstract]
- "Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells."Biochem. J. 270:545-548(1990) [PubMed] [Europe PMC] [Abstract]
- "Human liver protein map: a reference database established by microsequencing and gel comparison."Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
- , Submitted (DEC-2008) to UniProtKB
- "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
- "The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes."J. Exp. Med. 177:1-7(1993) [PubMed] [Europe PMC] [Abstract]
- "A two-dimensional gel database of human colon carcinoma proteins."Electrophoresis 18:605-613(1997) [PubMed] [Europe PMC] [Abstract]
- "Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase."J. Biol. Chem. 270:4741-4747(1995) [PubMed] [Europe PMC] [Abstract]
- "Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen."J. Immunol. 156:4484-4491(1996) [PubMed] [Europe PMC] [Abstract]
- "Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules."J. Biol. Chem. 274:16917-16922(1999) [PubMed] [Europe PMC] [Abstract]
- "Calreticulin is a receptor for nuclear export."J. Cell Biol. 152:127-140(2001) [PubMed] [Europe PMC] [Abstract]
- "Human placental calreticulin characterization of domain structure and post-translational modifications."Eur. J. Biochem. 268:2558-2565(2001) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain."J. Biol. Chem. 285:35551-35557(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Structural framework of the GABARAP-calreticulin interface --implications for substrate binding to endoplasmic reticulum chaperones."FEBS J. 276:1140-1152(2009) [PubMed] [Europe PMC] [Abstract]
- "X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism."PLoS ONE 6:E17886-E17886(2011) [PubMed] [Europe PMC] [Abstract]