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Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR)

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ADCYAP1-R1; ADCYAP1R1; PACAP-R; PACAPRI

Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR)
CCC B411
HGNC 242
MGI 108449
PubMed 9274830
RGD 2038
UniProt P41586
Wiki PACAPR1

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I is a receptor binds pituitary adenylate cyclase activating peptide.PAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase.

Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined. PAC1 is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor."Biochem. Biophys. Res. Commun. 196:1511-1521(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7."Genomics 23:697-699(1994) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants."J. Neuroendocrinol. 11:941-949(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."Proc. Natl. Acad. Sci. U.S.A. 104:7875-7880(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors."PLoS ONE 6:E19682-E19682(2011) [PubMed] [Europe PMC] [Abstract]