Cluster of Differentiation 79B (CD79B)

[Edit]

Igb; B29; Immunoglobulin-associated B29 protein; B-cell antigen receptor complex-associated protein beta chain

Cluster of Differentiation 79B (CD79B)

Immunoglobulin-associated beta, The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor.

This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.The deduced 229-amino acid protein has a hydrophobic leader sequence, an Ig-like domain, a positively charged extracellular domain, a transmembrane domain, and an intracytoplasmic tail containing a motif present in molecules involved in lymphocyte activation. Human and mouse B29 share 75% amino acid identity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB382Hu01 Recombinant Cluster of Differentiation 79B (CD79B) Positive Control; Immunogen; SDS-PAGE; WB.
EPB382Hu61 Eukaryotic Cluster of Differentiation 79B (CD79B) Positive Control; Immunogen; SDS-PAGE; WB.
APB382Hu61 Active Cluster of Differentiation 79B (CD79B) Cell culture; Activity Assays.
Antibodies PAB382Hu01 Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu26 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu21 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB.
MAB382Hu22 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu24 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu23 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu25 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu27 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu29 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
MAB382Hu28 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster of Differentiation 79B (CD79B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 79B (CD79B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB382Mu01 Recombinant Cluster of Differentiation 79B (CD79B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB382Mu01 Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster of Differentiation 79B (CD79B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 79B (CD79B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster of Differentiation 79B (CD79B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster of Differentiation 79B (CD79B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 79B (CD79B) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29."Eur. J. Immunol. 22:1621-1625(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)."Genomics 16:187-192(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes."J. Immunol. 150:491-498(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism."Immunogenetics 40:145-149(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells."Mol. Immunol. 32:651-659(1995) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex."Mol. Immunol. 31:419-427(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex."J. Biol. Chem. 271:5158-5163(1996) [PubMed] [Europe PMC] [Abstract]
  9. "B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta."Blood 89:1513-1520(1997) [PubMed] [Europe PMC] [Abstract]
  10. "B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta."J. Immunol. 169:865-872(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor."Structure 18:934-943(2010) [PubMed] [Europe PMC] [Abstract]
  13. "A hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development."J. Immunol. 179:2055-2059(2007) [PubMed] [Europe PMC] [Abstract]