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Cluster of Differentiation 79B (CD79B)

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Igb; B29; Immunoglobulin-associated B29 protein; B-cell antigen receptor complex-associated protein beta chain

Cluster of Differentiation 79B (CD79B)
CCC B382
HGNC 1699
MGI 96431
PubMed 10516749
RGD 620012
UniProt P40259
Wiki CD79B

Immunoglobulin-associated beta, The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor.

This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.The deduced 229-amino acid protein has a hydrophobic leader sequence, an Ig-like domain, a positively charged extracellular domain, a transmembrane domain, and an intracytoplasmic tail containing a motif present in molecules involved in lymphocyte activation. Human and mouse B29 share 75% amino acid identity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB382Hu01 Recombinant Cluster of Differentiation 79B (CD79B) Positive Control; Immunogen; SDS-PAGE; WB.
EPB382Hu61 Eukaryotic Cluster of Differentiation 79B (CD79B) Positive Control; Immunogen; SDS-PAGE; WB.
APB382Hu61 Active Cluster of Differentiation 79B (CD79B) Cell culture; Activity Assays.
Antibodies PAB382Hu01 Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; ICC/IF
MAB382Hu26 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; ICC/IF
MAB382Hu21 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; ICC/IF
MAB382Hu22 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB
MAB382Hu24 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB
MAB382Hu23 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB
MAB382Hu25 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB
MAB382Hu27 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB
MAB382Hu29 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) WB
MAB382Hu28 Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) ICC/IF
Assay Kits n/a CLIA Kit for Cluster of Differentiation 79B (CD79B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 79B (CD79B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB382Mu01 Recombinant Cluster of Differentiation 79B (CD79B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB382Mu01 Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) WB; IHC
Assay Kits n/a CLIA Kit for Cluster of Differentiation 79B (CD79B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 79B (CD79B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster of Differentiation 79B (CD79B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster of Differentiation 79B (CD79B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 79B (CD79B) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29."Eur. J. Immunol. 22:1621-1625(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)."Genomics 16:187-192(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes."J. Immunol. 150:491-498(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism."Immunogenetics 40:145-149(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells."Mol. Immunol. 32:651-659(1995) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex."Mol. Immunol. 31:419-427(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex."J. Biol. Chem. 271:5158-5163(1996) [PubMed] [Europe PMC] [Abstract]
  9. "B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta."Blood 89:1513-1520(1997) [PubMed] [Europe PMC] [Abstract]
  10. "B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta."J. Immunol. 169:865-872(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor."Structure 18:934-943(2010) [PubMed] [Europe PMC] [Abstract]
  13. "A hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development."J. Immunol. 179:2055-2059(2007) [PubMed] [Europe PMC] [Abstract]