Cluster of Differentiation 79B (CD79B)
[Edit]Igb; B29; Immunoglobulin-associated B29 protein; B-cell antigen receptor complex-associated protein beta chain
-91382.jpg)
Immunoglobulin-associated beta, The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor.
This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.The deduced 229-amino acid protein has a hydrophobic leader sequence, an Ig-like domain, a positively charged extracellular domain, a transmembrane domain, and an intracytoplasmic tail containing a motif present in molecules involved in lymphocyte activation. Human and mouse B29 share 75% amino acid identity.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB382Mu01 | Recombinant Cluster of Differentiation 79B (CD79B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB382Mu01 | Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) | WB; IHC |
| Assay Kits | n/a | CLIA Kit for Cluster of Differentiation 79B (CD79B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster of Differentiation 79B (CD79B) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cluster of Differentiation 79B (CD79B) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cluster of Differentiation 79B (CD79B) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cluster of Differentiation 79B (CD79B) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cluster of Differentiation 79B (CD79B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster of Differentiation 79B (CD79B) | ELISA Kit Customized Service Offer |
- "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29."Eur. J. Immunol. 22:1621-1625(1992) [PubMed] [Europe PMC] [Abstract]
- "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)."Genomics 16:187-192(1993) [PubMed] [Europe PMC] [Abstract]
- "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes."J. Immunol. 150:491-498(1993) [PubMed] [Europe PMC] [Abstract]
- "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism."Immunogenetics 40:145-149(1994) [PubMed] [Europe PMC] [Abstract]
- "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells."Mol. Immunol. 32:651-659(1995) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex."Mol. Immunol. 31:419-427(1994) [PubMed] [Europe PMC] [Abstract]
- "Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex."J. Biol. Chem. 271:5158-5163(1996) [PubMed] [Europe PMC] [Abstract]
- "B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta."Blood 89:1513-1520(1997) [PubMed] [Europe PMC] [Abstract]
- "B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta."J. Immunol. 169:865-872(2002) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor."Structure 18:934-943(2010) [PubMed] [Europe PMC] [Abstract]
- "A hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development."J. Immunol. 179:2055-2059(2007) [PubMed] [Europe PMC] [Abstract]