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5-Lipoxygenase (5-LO)

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LOX5; 5-LOX; ALOX-5; ALOX5; 5LPG; LOG5; Lipoxygenase 5

5-Lipoxygenase (5-LO)
CCC B355
HGNC 435
MGI 87999
PubMed 23600541
RGD 2096
UniProt P09917
Wiki ALOX5

Arachidonate 5-lipoxygenase is a member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.5-ALOX catalyzes oxidation of AA at the 5-position to yield 5-HPETE. 5-LO then converts 5-HPETE to leukotriene A4.5-ALOX is a target for pharmaceutical intervention in CAD.

Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-ALOX is expressed in brain cells and may participate in neuropathologic processes.Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB355Hu01 Recombinant 5-Lipoxygenase (5-LO) Positive Control; Immunogen; SDS-PAGE; WB.
RPB355Hu02 Recombinant 5-Lipoxygenase (5-LO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB355Hu01 Polyclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
MAB355Hu22 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB.
MAB355Hu21 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB
MAB355Hu23 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
MAB355Hu24 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
MAB355Hu25 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
MAB355Hu27 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
MAB355Hu29 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
Assay Kits SEB355Hu ELISA Kit for 5-Lipoxygenase (5-LO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB355Mu01 Recombinant 5-Lipoxygenase (5-LO) Positive Control; Immunogen; SDS-PAGE; WB.
RPB355Mu02 Recombinant 5-Lipoxygenase (5-LO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB355Mu01 Polyclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
PAB355Mu02 Polyclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
LAB355Mu71 Biotin-Linked Polyclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC.
Assay Kits SEB355Mu ELISA Kit for 5-Lipoxygenase (5-LO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB355Ra01 Recombinant 5-Lipoxygenase (5-LO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB355Ra01 Polyclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
MAB355Ra21 Monoclonal Antibody to 5-Lipoxygenase (5-LO) WB; IHC; ICC; IP.
Assay Kits SEB355Ra ELISA Kit for 5-Lipoxygenase (5-LO) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Molecular cloning and amino acid sequence of human 5-lipoxygenase."Proc. Natl. Acad. Sci. U.S.A. 85:26-30(1988) [PubMed] [Europe PMC] [Abstract]
  3. ErratumProc. Natl. Acad. Sci. U.S.A. 85:3406-3406(1988)
  4. "Molecular cloning and amino acid sequence of human 5-lipoxygenase."Adv. Prostaglandin Thromboxane Leukotriene Res. 19:466-469(1989) [PubMed] [Europe PMC] [Abstract]
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  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
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  9. "Characterization of the human 5-lipoxygenase gene promoter."Proc. Natl. Acad. Sci. U.S.A. 87:9073-9077(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase."Proc. Natl. Acad. Sci. U.S.A. 84:7393-7397(1987) [PubMed] [Europe PMC] [Abstract]
  11. "Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase."J. Biol. Chem. 266:22057-22062(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase."Biochem. Biophys. Res. Commun. 182:1482-1490(1992) [PubMed] [Europe PMC] [Abstract]
  13. "5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes."J. Exp. Med. 178:1935-1946(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)."J. Biol. Chem. 277:14793-14800(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523."J. Biol. Chem. 279:41512-41520(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils."J. Biol. Chem. 281:129-136(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein."Biochem. Biophys. Res. Commun. 381:518-522(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export."J. Biol. Chem. 284:306-313(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102."Biochem. J. 425:265-274(2010) [PubMed] [Europe PMC] [Abstract]
  20. "The structure of human 5-lipoxygenase."Science 331:217-219(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."Carcinogenesis 25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]