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Aryl Hydrocarbon Receptor (AhR)

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BHLHE76; Class E basic helix-loop-helix protein 76

Aryl Hydrocarbon Receptor (AhR)
CCC B354
HGNC 348
MGI 105043
PubMed 18540824
RGD 2074
UniProt P35869
Wiki AHR

The Aryl hydrocarbon receptor is a member of the family of basic-helix-loop-helix transcription factors. Halogenated aromatic hydrocarbons, represented by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are environmental pollutants that are produced by minor side-reactions in chemical manufacturing processes and by combustion of waste materials.

These chemicals cause potent and pleiotropic toxicity, including teratogenesis, immune suppression, epithelial disorders, and tumor production in experimental animals. At the molecular level, aldehyde dehydrogenase, quinone reductase, and various drug-metabolizing enzymes are induced by the chemicals in some cultured cells and some tissues of experimental animals. All these biologic effects are thought to be mediated by an intracellular aryl hydrocarbon receptor (AHR).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB354Hu01 Recombinant Aryl Hydrocarbon Receptor (AhR) Positive Control; Immunogen; SDS-PAGE; WB.
APB354Hu01 Active Aryl Hydrocarbon Receptor (AhR) Cell culture; Activity Assays.
Antibodies PAB354Hu01 Polyclonal Antibody to Aryl Hydrocarbon Receptor (AhR) WB; IHC; ICC/IF
MAB354Hu22 Monoclonal Antibody to Aryl Hydrocarbon Receptor (AhR) WB; IHC; ICC; IP.
MAB354Hu21 Monoclonal Antibody to Aryl Hydrocarbon Receptor (AhR) WB; IHC; ICC; IP.
Assay Kits SEB354Hu ELISA Kit for Aryl Hydrocarbon Receptor (AhR) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB354Hu CLIA Kit for Aryl Hydrocarbon Receptor (AhR) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB354Mu01 Recombinant Aryl Hydrocarbon Receptor (AhR) Positive Control; Immunogen; SDS-PAGE; WB.
APB354Mu01 Active Aryl Hydrocarbon Receptor (AhR) Cell culture; Activity Assays.
Antibodies PAB354Mu01 Polyclonal Antibody to Aryl Hydrocarbon Receptor (AhR) WB; IHC; ICC; IP.
Assay Kits SEB354Mu ELISA Kit for Aryl Hydrocarbon Receptor (AhR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB354Ra01 Recombinant Aryl Hydrocarbon Receptor (AhR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB354Ra01 Polyclonal Antibody to Aryl Hydrocarbon Receptor (AhR) WB; IHC; ICC; IP.
MAB354Ra21 Monoclonal Antibody to Aryl Hydrocarbon Receptor (AhR) WB; IHC; ICC; IP.
Assay Kits SEB354Ra ELISA Kit for Aryl Hydrocarbon Receptor (AhR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human Ah receptor cDNA: analysis for highly conserved sequences."Nucleic Acids Res. 21:3578-3578(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of a human Ah receptor cDNA."Mol. Pharmacol. 44:911-917(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21."J. Biochem. 116:845-851(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Complete structural characterisation of the human aryl hydrocarbon receptor gene."Clin. Mol. Pathol. 49:M12-M16(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Interindividual difference in expression of human Ah receptor and related P450 genes."Carcinogenesis 15:801-806(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors."J. Biol. Chem. 269:27337-27343(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex."Arch. Biochem. Biophys. 367:250-257(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1)."Mol. Pharmacol. 59:716-724(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Role of the aryl hydrocarbon receptor in cell cycle regulation."Chem. Biol. Interact. 141:117-130(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor."J. Biol. Chem. 277:44028-44034(2002) [PubMed] [Europe PMC] [Abstract]
  14. "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein."Mol. Pharmacol. 70:8-15(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Polymorphisms in the human AH receptor."Chem. Biol. Interact. 141:161-187(2002) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Polymorphisms of human Ah receptor gene are not involved in lung cancer."Pharmacogenetics 5:151-158(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms."Pharmacogenetics 10:11-24(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer."Carcinogenesis 22:1819-1824(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction."Biochem. Biophys. Res. Commun. 288:990-996(2001) [PubMed] [Europe PMC] [Abstract]