Beta-1,3-Glucuronyltransferase 1 (b3GAT1)

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CD57; B3-GAT1; GLCATP; GlcAT-P; GlcUAT-P; HNK-1; LEU7; NK-1; Glucuronosyltransferase P; Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 1

Beta-1,3-Glucuronyltransferase 1 (b3GAT1)

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.

It is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7).

Alternate transcriptional splice variants have been characterized.In immunology, the CD57 antigen (CD stands for cluster of differentiation) is a protein which is also called HNK1 (human natural killer-1) or LEU7. It is a neuronally expressed adhesion molecule with a carbohydrate epitope that contains a sulfoglucuronyl residue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB334Hu01 Recombinant Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Positive Control; Immunogen; SDS-PAGE; WB.
EPB334Hu61 Eukaryotic Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Positive Control; Immunogen; SDS-PAGE; WB.
APB334Hu61 Active Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Cell culture; Activity Assays.
Antibodies PAB334Hu01 Polyclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) WB; IHC; ICC; IP.
MAB334Hu21 Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) WB; IHC; ICC; IP.
MAB334Hu26 Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) WB; IHC; ICC; IP.
MAB334Hu22 Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) WB; IHC; ICC; IP.
MAB334Hu23 Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) WB; IHC; ICC; IP.
MAB334Hu24 Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) WB; IHC; ICC; IP.
Assay Kits SEB334Hu ELISA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) ELISA Kit Customized Service Offer
  1. "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope."Genomics 65:166-173(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1."J. Biol. Chem. 279:22693-22703(2004) [PubMed] [Europe PMC] [Abstract]