Beta-1,3-Glucuronyltransferase 1 (b3GAT1)
[Edit]CD57; B3-GAT1; GLCATP; GlcAT-P; GlcUAT-P; HNK-1; LEU7; NK-1; Glucuronosyltransferase P; Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 1
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
It is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7).
Alternate transcriptional splice variants have been characterized.In immunology, the CD57 antigen (CD stands for cluster of differentiation) is a protein which is also called HNK1 (human natural killer-1) or LEU7. It is a neuronally expressed adhesion molecule with a carbohydrate epitope that contains a sulfoglucuronyl residue.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Beta-1,3-Glucuronyltransferase 1 (b3GAT1) | ELISA Kit Customized Service Offer |
- "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope."Genomics 65:166-173(2000) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1."J. Biol. Chem. 279:22693-22703(2004) [PubMed] [Europe PMC] [Abstract]