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Melanoma Associated ME20 (ME20M)

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PMEL; GP100; SI; SIL; SILV; Pmel17; Silver Homolog; Premelanosome Protein; Silver Locus Protein Homolog; 95 kDa melanocyte-specific secreted glycoprotein

Melanoma Associated ME20 (ME20M)
CCC B330
HGNC 10880
MGI 98301
PubMed 8185325
RGD 1307513
UniProt P40967
Wiki SILV

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB330Hu01 Recombinant Melanoma Associated ME20 (ME20M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB330Hu01 Polyclonal Antibody to Melanoma Associated ME20 (ME20M) WB; IHC; ICC; IP.
MAB330Hu22 Monoclonal Antibody to Melanoma Associated ME20 (ME20M) WB; IHC; ICC; IP.
Assay Kits SEB330Hu ELISA Kit for Melanoma Associated ME20 (ME20M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melanoma Associated ME20 (ME20M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melanoma Associated ME20 (ME20M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanoma Associated ME20 (ME20M) Polyclonal Antibody Customized Service Offer
Assay Kits SEB330Mu ELISA Kit for Melanoma Associated ME20 (ME20M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melanoma Associated ME20 (ME20M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melanoma Associated ME20 (ME20M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanoma Associated ME20 (ME20M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melanoma Associated ME20 (ME20M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melanoma Associated ME20 (ME20M) ELISA Kit Customized Service Offer
  1. "A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12."Proc. Natl. Acad. Sci. U.S.A. 88:9228-9232(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of the gene for the melanoma-associated ME20 antigen."DNA Cell Biol. 13:87-95(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular characterization of the melanocyte lineage-specific antigen gp100."J. Biol. Chem. 269:20126-20133(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection."Proc. Natl. Acad. Sci. U.S.A. 91:6458-6462(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus."J. Invest. Dermatol. 106:24-27(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization and FISH mapping of human Pmel 17, the putative silver locus."Pigment Cell Res. 9:42-48(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats."J. Invest. Dermatol. 121:821-830(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Pmel17 initiates premelanosome morphogenesis within multivesicular bodies."Mol. Biol. Cell 12:3451-3464(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis."J. Cell Biol. 161:521-533(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment."J. Biol. Chem. 279:28330-28338(2004) [PubMed] [Europe PMC] [Abstract]
  15. "MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes."J. Biol. Chem. 280:14006-14016(2005) [PubMed] [Europe PMC] [Abstract]
  16. "The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers."J. Biol. Chem. 281:21198-21208(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Premelanosome amyloid-like fibrils are composed of only Golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes."J. Biol. Chem. 283:2307-2322(2008) [PubMed] [Europe PMC] [Abstract]
  19. "The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis."Dev. Cell 21:708-721(2011) [PubMed] [Europe PMC] [Abstract]