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Protein Tyrosine Phosphatase Receptor Type O (PTPRO)

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PTPR-O; GLEPP1; PTP-U2; PTPU2; Osteoclastic Transmembrane Protein-Tyrosine Phosphatase; Glomerular Epithelial Protein-1; Protein tyrosine phosphatase U2

Protein Tyrosine Phosphatase Receptor Type O (PTPRO)
CCC B321
HGNC 9678
MGI 1097152
PubMed 15673668
RGD 62068
UniProt Q16827
Wiki PTPRO

Receptor-type tyrosine-protein phosphatase O is tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. 

It is a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif.

The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.

The human GLEPP1 gene predicts a protein of 1,188 amino acids. The 1,159-amino acid predicted mature protein contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB321Hu01 Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB321Mu01 Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB321Mu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) WB
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) ELISA Kit Customized Service Offer
  1. "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents."Oncogene 10:1731-1738(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13."Genomics 27:174-181(1995) [PubMed] [Europe PMC] [Abstract]
  3. "PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest."Blood 94:2403-2413(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Disruption of PTPRO causes childhood-onset nephrotic syndrome."Am. J. Hum. Genet. 89:139-147(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Structural genomics of protein phosphatases." J. Struct. Funct. Genomics 8:121-140(2007) [PubMed] [Europe PMC] [Abstract]