Progesterone Receptor (PGR)

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NR3C3; PR; Nuclear Receptor Subfamily 3,Group C,Member 3

Progesterone Receptor (PGR)
The PR) also known as NR3C3 (nuclear receptor subfamily 3, group C, member 3), is an intracellular steroid receptor that specifically binds progesterone.
PR is encoded by a single gene PGR residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight.Like all steroid receptors, the progesterone receptor has an amino and a carboxyl terminal, and between them the regulatory domain, a DNA binding domain, the hinge section, and the hormone binding domain. A special transcription activation function (TAF), called TAF-3, is present in the progesterone receptor-B, in a B-upstream segment (BUS) at the amino acid terminal. This segment is not present in the receptor-A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB273Hu01 Recombinant Progesterone Receptor (PGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB273Hu02 Recombinant Progesterone Receptor (PGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB273Hu03 Recombinant Progesterone Receptor (PGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB273Hu01 Polyclonal Antibody to Progesterone Receptor (PGR) WB; IHC; ICC; IP.
MAB273Hu22 Monoclonal Antibody to Progesterone Receptor (PGR) WB; IHC; ICC; IP.
Assay Kits SEB273Hu ELISA Kit for Progesterone Receptor (PGR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Progesterone Receptor (PGR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Progesterone Receptor (PGR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Progesterone Receptor (PGR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Progesterone Receptor (PGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Progesterone Receptor (PGR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB273Ra01 Recombinant Progesterone Receptor (PGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB273Ra01 Polyclonal Antibody to Progesterone Receptor (PGR) WB; IHC; ICC; IP.
Assay Kits SEB273Ra ELISA Kit for Progesterone Receptor (PGR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB273Ca01 Recombinant Progesterone Receptor (PGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Progesterone Receptor (PGR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Progesterone Receptor (PGR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Progesterone Receptor (PGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Progesterone Receptor (PGR) ELISA Kit Customized Service Offer
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  8. "A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration."Mol. Endocrinol. 27:741-753(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor."Mol. Endocrinol. 9:1029-1040(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system."J. Biol. Chem. 271:19546-19555(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo."Mol. Endocrinol. 11:823-832(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody."Mol. Endocrinol. 14:52-65(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome."Proc. Natl. Acad. Sci. U.S.A. 97:1032-1037(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
  15. "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."Mol. Cell. Biol. 23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2."Mol. Cell. Biol. 24:10542-10557(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity."Mol. Cell. Biol. 25:2885-2898(2005) [PubMed] [Europe PMC] [Abstract]
  18. "GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway."Mol. Cell. Biol. 26:1722-1730(2006) [PubMed] [Europe PMC] [Abstract]
  19. "PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus."Nucleic Acids Res. 34:5552-5566(2006) [PubMed] [Europe PMC] [Abstract]
  20. "CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome."EMBO J. 26:1831-1842(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells."Mol. Endocrinol. 21:2890-2906(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth."Steroids 72:188-201(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors."Mol. Endocrinol. 22:823-837(2008) [PubMed] [Europe PMC] [Abstract]
  24. "DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."Mol. Biol. Cell 23:188-199(2012) [PubMed] [Europe PMC] [Abstract]
  25. "Atomic structure of progesterone complexed with its receptor."Nature 393:392-396(1998) [PubMed] [Europe PMC] [Abstract]
  26. "Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget."J. Biol. Chem. 280:28468-28475(2005) [PubMed] [Europe PMC] [Abstract]