Dual Oxidase Maturation Factor 1 (DUOXA1)

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NUMBIP; NIP; Mol; Numb-interacting protein

Dual Oxidase Maturation Factor 1 (DUOXA1)
By searching a human database for orthologs of Drosophila 'Numb -interacting protein' (Nip), Qin et al. (2004) identified DUOXA1, which they called NIP. The deduced 470-amino acid transmembrane protein has a putative phosphotyrosine-binding (PTB) domain-binding motif.DUOXA1 gene is immediately adjacent in tail-to-tail orientation to the DUOXA2 gene on 15q15 and extends via untranslated exons into the DUOX1 promoter region.
By searching a database for sequences similar to DUOXA2, followed by RT-PCR of human thyroid tissue, Grasberger and Refetoff (2006) cloned DUOXA1. Northern blot analysis detected DUOXA1 transcripts of about 2.9 and 3.5 kb predominantly expressed in thyroid. Weaker expression was detected in esophagus, but not in any other tissue examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase Maturation Factor 1 (DUOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase Maturation Factor 1 (DUOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase Maturation Factor 1 (DUOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase Maturation Factor 1 (DUOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase Maturation Factor 1 (DUOXA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase Maturation Factor 1 (DUOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase Maturation Factor 1 (DUOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase Maturation Factor 1 (DUOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase Maturation Factor 1 (DUOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase Maturation Factor 1 (DUOXA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Oxidase Maturation Factor 1 (DUOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Oxidase Maturation Factor 1 (DUOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Oxidase Maturation Factor 1 (DUOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Oxidase Maturation Factor 1 (DUOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Oxidase Maturation Factor 1 (DUOXA1) ELISA Kit Customized Service Offer
  1. "Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent."J. Biol. Chem. 281:18269-18272(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division."J. Biol. Chem. 279:11304-11312(2004) [PubMed] [Europe PMC] [Abstract]